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Vitamins and blood changes during levodopa treatment

This study investigates vitamin B12, folate and entacapone in people with raised levels of the blood substance homocysteine.

Testing a treatment or activity · Study reference: TCTR20181221001

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Start (reported date)
2019-01-02
Study finished (reported date)
2020-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 40 years to 90 years · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: both

Inclusion criteria: The PD patients who are being treated with levodopa at least 300 mg/day for at least 1 year. Exclusion criteria: 1. Patients who are being treated with entacapone 2. Patients who are taking vitamin B12 or folate supplement. 3. Presence of the conditions influence homocysteine level are end stage renal disease, liver cirrhosis, smoking, malignancy, dementia, diabetes mellitus, hypothyroid, take thaizide diuretic, azathioprine, phenytoin, metrotrexate
Full study name & original research details

Official study title

Effect of Vitamin B12, Folate, and Entacapone in Levodopa-induced hyperhomocysteinemia

Original description

Intervention: Take 12 weeks of vitamin B12 0.5 mg plus folate 5 mg ,Take 12 weeks of entacapone titrate up to at least 600 mg/day,Control group No intervention;Active Comparator Dietary Supplement,Active Comparator Drug,No Intervention No treatment;vitamin B12 plus folate,entacapone,No intervention Primary outcome: Serum homocysteine level at weeks 6 and 12 after treatment Blood testing Secondary outcome: N/A N/A N/A

Conditions reported: Parkinson's disease Parkinson's disease, Levodopa, Hyperhomocysteinemia, Entacapone, Vitamin B12, Folate;Parkinson's disease, Levodopa, Hyperhomocysteinemia, Entacapone, Vitamin B12, Folate

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Take 12 weeks of vitamin B12 0.5 mg plus folate 5 mg ,Take 12 weeks of entacapone titrate up to at least 600 mg/day,Control group No intervention;Active Comparator Dietary Supplement,Active Comparator Drug,No Intervention No treatment;vitamin B12 plus folate,entacapone,No intervention
Phases
N/A
Sponsor
Research and Development Center, Prapokklao Hospital
Start date reported by registry
2019-01-02 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Chumpol Anamnart · 0814306100 · tom_ppk@yahoo.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Thailand

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.