Recruiting · registry status

Fast strength exercises and heart and brain health

This study investigates responses to a session of strength training in people with Parkinson's.

Testing a treatment or activity · Study reference: RBR-9g9b779

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

Open the official registry record ↗

Follow this study

Results reported

Start (reported date): 2025-07-11
Study finished (reported date): 2025-12-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

Read the results reported in the registry

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 40y to 0 · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: -

Inclusion criteria: Men and women; diagnosed with Parkinson's disease according to MDS-UPDRS criteria; stages I to III on the modified Hoehn & Yahr scale; no changes in medication regimen for at least 4 weeks; literate; able to perform basic activities of daily living independently with a Schwab and England scale score of at least 80%; age equal to or greater than 40 years Exclusion criteria: Body mass index greater than 40 or less than 20; diagnosis of specific diseases such as Crohn's disease, ulcerative colitis, multiple sclerosis; clinical and psychological conditions that may interfere with participation or study results

Full study name & original research details

Official study title

Acute effect of potent strength training on cardiovascular parameters and neurotrophic and inflammatory biomarkers in patient with Parkinson's disease of mild to moderate

Short title used by the registry

Speed strength training and its effects on heart and brain health in people with Parkinson's disease

Original description

Intervention: The study will be a randomized controlled crossover clinical trial. Intervention group: 22 participants with Parkinson's disease will undergo a single powerful strength training session consisting of 60 minutes of exercises with elastic bands and tubes. Each exercise will be performed in three sets of 8 submaximal repetitions, at moderate intensity, with a 1-minute break between sets. The concentric phase will be performed as quickly as possible, while the eccentric phase will have a controlled duration of two seconds. Control group: 22 participants with Parkinson's disease will perform a single 60-minute session at rest, alternating their positions according to the order of the exercises in the intervention group, without performing the movements. The sample will be recruited and characterized using the RedCap platform, where the data will be stored and organized. Randomization will be carried out by a simple 1-to-1 draw, in blocks of two participants per group. Masking will be simple and the outcome assessors will be blinded to the allocation of participants to the groups;G11.427.410.698.277;E02.760.169.063.500.387.875 Primary outcome: Evaluate BDNF, PROBDNF, NGF, PRO-NGF, IGF1, IL6, IL10, TNF, NGFR (p75NTR), TrK1 (NTRK1), TrK2 (NTRK2), and NF-kappa-B p65 (RELA) through blood analysis using the RT-qPCR method, with RNA extraction, quantification by Nanodrop, and cDNA synthesis with GoScript™ Reverse Transcriptase Secondary outcome: Assess cortisol, oxytocin, IL6, IL1ß, IL8, and IL4 levels through saliva analysis using the ELISA method;Evaluate the SDNN, RMSSD, pNN50, VLF, LF, HF, and LF/HF ratio parameters of heart rate variability(HRV) by analyzing beat-to-beat signals (iRR) that have been filtered, processed, and analyzed in the time and frequency domains

Conditions reported: Parkinson disease;C10.574

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

REBEC · RBR-9g9b779 ↗ — Recruiting; WHO ICTRP processed 2025-10-27; checked 2026-10-11

Study type: Interventional
Interventions: The study will be a randomized controlled crossover clinical trial. Intervention group: 22 participants with Parkinson's disease will undergo a single powerful strength training session consisting of 60 minutes of exercises with elastic bands and tubes. Each exercise will be performed in three sets of 8 submaximal repetitions, at moderate intensity, with a 1-minute break between sets. The concentric phase will be performed as quickly as possible, while the eccentric phase will have a controlled duration of two seconds. Control group: 22 participants with Parkinson's disease will perform a single 60-minute session at rest, alternating their positions according to the order of the exercises in the intervention group, without performing the movements. The sample will be recruited and characterized using the RedCap platform, where the data will be stored and organized. Randomization will be carried out by a simple 1-to-1 draw, in blocks of two participants per group. Masking will be simple and the outcome assessors will be blinded to the allocation of participants to the groups;G11.427.410.698.277;E02.760.169.063.500.387.875
Phases: N/A
Sponsor: Hospital Universitário Walter Cantídio da Universidade Federal do Ceará
Start date reported by registry: 2025-07-11 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Carlos Eduardo Da Silva · +55(85)986291992 · carlosedurbano789@gmail.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Brazil

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.