Recruiting · registry status

Exercise for hand movements

This study compares exercise approaches to investigate hand skills, movement and changes in brain function in Parkinson's.

Testing a treatment or activity · Study reference: RBR-7zjgnrx

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Results reported

Start (reported date): 2022-06-01
Study finished (reported date): 2024-02-28

Planned dates can move. A study finishing does not tell us when a paper will be published.

Read the results reported in the registry

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

Upper Limb Exercises Reduce Non-motor Symptoms and Increase Cognitive Function in Parkinson's Disease: Randomized Controlled Trial.
This paper mentions the study ID; the relationship needs review · 2026

Resting-State EEG Alpha Asymmetry as a Potential Marker of Clinical Features in Parkinson’s Disease
This paper mentions the study ID; the relationship needs review · 2025

Who can join?

Ages 40y to 80y · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: -

Inclusion criteria: The inclusion criteria will be age between 40 to 80 years; both genders; diagnosis of Parkinson's disease as confirmed by neurologist; stage 1-3 on the Hoeh and Yahr scale; who were not exercising at moderate intensity greater than 3 times per week within 3 months; complaints about motor impairments related to hand function (self-report); taking stable medications for Parkinson's disease for at least 30 days Exclusion criteria: The exclusion criteria will be features suggestive of other causes of parkinsonism/ Parkinson’s-plus syndromes, unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure, uncompensated pulmonary disease, or chronic obstructive pulmonary disease), psychiatric diseases diagnosed by a psychiatrist; dementia (Mini-Mental State Examination score less than 24), presence of another neurological disorder and hearing or visual impairment

Full study name & original research details

Official study title

Effects of Physical Exercise in motor function, manual dexterity and brain plasticity in individuals with Parkinson's disease: randomized controlled trial

Short title used by the registry

Effects of Physical Exercise in movements, manual hability and brain plasticity in individuals with Parkinson's disease

Original description

Intervention: Randomized clinical trial, 40 patients with Parkinson's disease aged 40-80 years with motor impairments related to hand function will be recruited and separated in four groups: aerobic training (AT), strength training (ST) task oriented training (TOT), and waiting list group (CG). The AT group will be performed 30 minutes of cycle ergometer on 50-70% of the reserve heart rate in each session; the ST group will be used equipment for upper limb muscles with a volume of training of two series of 8 to 12 repetitions for each exercise with rest intervals of 2 minutes between the sets, and the intensity between 50-70 % of one maximum repetition, according to Borg scale. The TOT group will perform a program consisting of three activities to enhance reaching, grasping and manipulation, for 30 minutes. The CG will be the Parkinson's disease patients on the waiting list for the exercise intervention. All the groups will perform sessions, 3x/week for 8 weeks.;G11.427.410.698.277 Primary outcome: The primary outcome will be the Unified Parkinson’s Disease Rating Scale (UPDRS): motor function part III that is a comprehensive assessment designed to assess Parkinson's disease across the disease course and provide clinical endpoints in therapy trials. We hypothesized that there will be clinically relevant improvement after interventions compared to control. Secondary outcome: The secondary objective is evaluate the neuroplasticity effects of those interventions indexed by resting and task-related quantitative electroencephalography (motor execution, motor observation, and motor imagery). Our hypothesis is that there will be higher spectral power at high-frequencies bands (alpha and beta), and higher beta-ERS in the sensorimotor areas after exercise protocols compared with control groups; we hypothesized that electroencephalography changes will correlate with the upper limb function improvement indexed by UPDRS III.;The secondary outcome manual dexterity will be measured by the Nine-Hole Peg Test (9-HPT). We hypothesized that there will be clinically relevant improvement after interventions compared to control.

Conditions reported: Parkinson disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

REBEC · RBR-7zjgnrx ↗ — Recruiting; WHO ICTRP processed 2025-10-27; checked 2026-10-11

Study type: Interventional
Interventions: Randomized clinical trial, 40 patients with Parkinson's disease aged 40-80 years with motor impairments related to hand function will be recruited and separated in four groups: aerobic training (AT), strength training (ST) task oriented training (TOT), and waiting list group (CG). The AT group will be performed 30 minutes of cycle ergometer on 50-70% of the reserve heart rate in each session; the ST group will be used equipment for upper limb muscles with a volume of training of two series of 8 to 12 repetitions for each exercise with rest intervals of 2 minutes between the sets, and the intensity between 50-70 % of one maximum repetition, according to Borg scale. The TOT group will perform a program consisting of three activities to enhance reaching, grasping and manipulation, for 30 minutes. The CG will be the Parkinson's disease patients on the waiting list for the exercise intervention. All the groups will perform sessions, 3x/week for 8 weeks.;G11.427.410.698.277
Phases: N/A
Sponsor: Laboratório de Neurociências - Universidade Federal de São Carlos
Start date reported by registry: 2022-06-01 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Maryela de Menacho · +55(69)981003773 · maryelamenacho@estudante.ufscar.br

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Brazil

Status not reported

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.