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Exercise with or without thinking tasks

This study compares aerobic exercise approaches and investigates walking, balance, brain activity and Parkinson's symptoms.

Testing a treatment or activity · Study reference: RBR-7t8vqrz

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Results reported

Start (reported date)
2022-05-15
Study finished (reported date)
2023-12-30

Planned dates can move. A study finishing does not tell us when a paper will be published.

Read the results reported in the registry

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 50y to 85y · Ask the team who can join

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Sex eligibility reported by registry: -

Inclusion criteria: Parkinson´s disease severity at II-III stage according to the modified Hoen Yahr scale; Age between 50 and 85 years old; Global cognition with a score greater than 21 for individuals with schooling between 4 and 12 years, and greater than 20 for individuals with more than 12 years of schooling, according to the Monttreal Cognitive Assessment (MoCa), portuguese version; and being a faller (i.e., more than 2 falls in the last 6 months) Exclusion criteria: Not have had training in the last 6 months; No othe neurological disorder (beyond idiopathic Parkinson´s disease; Do not use AChE inhibitors (e.g., rivastigmine, donepezil, galantamine and tacrine), benzodiazepine, neuroleptic or tricyclic antidepressants; Not having resting tremor with a score greater than 2 (i.e., excessive tremor); and not present Freezing of Gait
Full study name & original research details

Official study title

Effects of Resistance Training with and without Cognitive tasks on the Automaticity of Gait, Postural Instability, Cholinergic Activity, prefrontal cortex activity and Motor Symptoms Severity of individuals with Parkinson´s disease: A randomized double Blind study

Short title used by the registry

Effects of Aerobic Exercise with and without Cognitive Tasks on Gait control, Balance, Acetylcholine neurotransmitter Activity, activity of front part of the Brain and Symptoms of people with Parkinson´s disease

Original description

Intervention: The 46 Participants will be divided into two groups: Endurance Training (ET) and Endurance Training plus cognitive Taks (ET+COG). Both with 23 participants. They will train three times a week for six months. Each session will last na average of 60 minutes. The intensity of interventions will be controlled by relative heart rate and perceived exertion. All participants will train on moderate and vigorou intensity. In addition, they will be evaluated through clinical (cognitive scales, MDS-UPDRS-III, postural instability, recordatory of falls and gait automaticity) and neurophysiological tests (cholinergic activity- short afferent inhibition and brain activity-FNIRS). The evaluations will be divided into four moments (pre T1, T1, T2 and T3) with two days of evaluations for each moment. The pre T1 and T1 will serve to determine reability, reproducibility and Minimal Detectable Change (7 days between moments), and T1 will be considered as the initial values (i.e., baseline). Moment T2- Assessments after 6 months of ET and ET+COG (i.e., 3 months of Follow-Up);Z72.3 Primary outcome: Primary outcome- ET+COG will be more effective than ET alone in improving gait automaticity (our primary outcome) in people with Parkinson´s Disease (PD). Gait automaticity will be evaluated through the variability of gait parameters (most debilitating in PD) in a single task, but also in a dual task Secondary outcome: Secondary outcome- ET+COG will be more effective than ET alone in increase cholinergic activity (our principal secondary outcome) of people with Parkinson´s Disease. Cholinergic activity will be evaluated through Short Latency Afferent Inhibition, which is a paired pulse neurophysiological technique

Conditions reported: Other anormalities of gait and mobility; Loss of Gait automaticity in Parkinsos´s Disease; Gait problems

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
The 46 Participants will be divided into two groups: Endurance Training (ET) and Endurance Training plus cognitive Taks (ET+COG). Both with 23 participants. They will train three times a week for six months. Each session will last na average of 60 minutes. The intensity of interventions will be controlled by relative heart rate and perceived exertion. All participants will train on moderate and vigorou intensity. In addition, they will be evaluated through clinical (cognitive scales, MDS-UPDRS-III, postural instability, recordatory of falls and gait automaticity) and neurophysiological tests (cholinergic activity- short afferent inhibition and brain activity-FNIRS). The evaluations will be divided into four moments (pre T1, T1, T2 and T3) with two days of evaluations for each moment. The pre T1 and T1 will serve to determine reability, reproducibility and Minimal Detectable Change (7 days between moments), and T1 will be considered as the initial values (i.e., baseline). Moment T2- Assessments after 6 months of ET and ET+COG (i.e., 3 months of Follow-Up);Z72.3
Phases
N/A
Sponsor
Escola de Educação Física e Esporte da Universidade de São Paulo
Start date reported by registry
2022-05-15 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Jumes Lira · 55 11 963596193 · jumeslira@usp.br

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Brazil

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.