Recruiting · registry status

Magnetic brain stimulation and thinking skills

Researchers are comparing active and simulated stimulation to investigate memory, attention and reasoning, including in people with Parkinson's.

Testing a treatment or activity · Study reference: RBR-1068g8pp

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Results reported

Start (reported date): 2025-02-03
Study finished (reported date): 2028-03-04

Planned dates can move. A study finishing does not tell us when a paper will be published.

Read the results reported in the registry

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18y to 80y · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: -

Inclusion criteria: Adults aged 18 to 80 years, of either sex; individuals without neurological comorbidities or with a clinical diagnosis of Parkinson’s disease or Alzheimer’s disease; ability to undergo the planned cognitive assessments and transcranial magnetic stimulation procedures; agreement to participate by signing the informed consent form, directly or through a legal representative when applicable Exclusion criteria: History of epilepsy or unprovoked seizures; severe or unstable clinical conditions that contraindicate participation in the study; contraindications to transcranial magnetic stimulation identified on clinical screening or according to device safety recommendations; inability to complete the proposed assessments or stimulation procedures; refusal to sign the informed consent form, directly or through a legal representative when applicable

Full study name & original research details

Official study title

Effect of Transcranial Magnetic Stimulation on cognitive performance in students

Short title used by the registry

Study of magnetic brain stimulation and memory, attention, and reasoning in students

Original description

Intervention: This is a randomized, double-blind, sham-controlled clinical trial in adults aged 18 to 80 years, conducted in three clinical cohorts: adults without neurological comorbidities, patients with Parkinson’s disease, and patients with Alzheimer’s disease. Participants in each cohort will be randomly allocated in a 1:1 ratio to active repetitive transcranial magnetic stimulation (rTMS) or sham stimulation. The minimum planned sample is 120 participants: 60 adults without neurological comorbidities, 30 patients with Parkinson’s disease, and 30 patients with Alzheimer’s disease. All participants will undergo baseline assessment before the first stimulation session and repeat the post-intervention assessment immediately after the 20th session. Evaluations will include validated neuropsychological tests appropriate to the participant’s clinical cohort, as well as sleep assessment using the Pittsburgh Sleep Quality Index (PSQI). The intervention will consist of 20 stimulation sessions. In adults without neurological comorbidities, active rTMS will be delivered over the left dorsolateral prefrontal cortex (F3). In Parkinson’s disease and Alzheimer’s disease cohorts, active rTMS will be delivered over two targets, F3 and P3. Stimulation parameters will follow the protocol defined for each clinical cohort. Sham stimulation will reproduce the same session structure and duration without delivering active therapeutic magnetic stimulation, preserving blinding conditions. A randomly selected subgroup of participants from all cohorts and from both study arms (active and sham) may undergo non-contrast brain magnetic resonance imaging (MRI) before the start of the intervention. After completion of the study protocol applicable to the participant, a final non-contrast br Primary outcome: Change in cognitive performance and sleep quality from baseline to immediately after the 20th stimulation session, assessed through validated neuropsychological tests and the Pittsburgh Sleep Quality Index (PSQI), according to the participant’s clinical cohort. Secondary outcome: Occurrence, frequency, and severity of adverse events related to the intervention, evaluated throughout the stimulation sessions and follow-up period, in order to assess the safety and tolerability of transcranial magnetic stimulation.;Subjective perception of changes related to the intervention, including perceived cognitive performance, sleep quality, attention, concentration, well-being, and performance in daily activities, assessed through participant-reported measures.

Conditions reported: Alzheimer's disease, Parkinson's disease, Healthy Volunteers Cognition;F02.463.188

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

REBEC · RBR-1068g8pp ↗ — Recruiting; WHO ICTRP processed 2026-04-27; checked 2026-10-11

Study type: Interventional
Interventions: This is a randomized, double-blind, sham-controlled clinical trial in adults aged 18 to 80 years, conducted in three clinical cohorts: adults without neurological comorbidities, patients with Parkinson’s disease, and patients with Alzheimer’s disease. Participants in each cohort will be randomly allocated in a 1:1 ratio to active repetitive transcranial magnetic stimulation (rTMS) or sham stimulation. The minimum planned sample is 120 participants: 60 adults without neurological comorbidities, 30 patients with Parkinson’s disease, and 30 patients with Alzheimer’s disease. All participants will undergo baseline assessment before the first stimulation session and repeat the post-intervention assessment immediately after the 20th session. Evaluations will include validated neuropsychological tests appropriate to the participant’s clinical cohort, as well as sleep assessment using the Pittsburgh Sleep Quality Index (PSQI). The intervention will consist of 20 stimulation sessions. In adults without neurological comorbidities, active rTMS will be delivered over the left dorsolateral prefrontal cortex (F3). In Parkinson’s disease and Alzheimer’s disease cohorts, active rTMS will be delivered over two targets, F3 and P3. Stimulation parameters will follow the protocol defined for each clinical cohort. Sham stimulation will reproduce the same session structure and duration without delivering active therapeutic magnetic stimulation, preserving blinding conditions. A randomly selected subgroup of participants from all cohorts and from both study arms (active and sham) may undergo non-contrast brain magnetic resonance imaging (MRI) before the start of the intervention. After completion of the study protocol applicable to the participant, a final non-contrast br
Phases: 4
Sponsor: Clínica Sinedor Ltda
Start date reported by registry: 2025-02-03 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Guilherme de Paula · +55(66)99913-7819 · gui_oliveira.16@hotmail.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.