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Past pesticide exposure and Parkinson's

Researchers are comparing lifetime pesticide exposure in people with and without Parkinson's to investigate possible associations.

Learning by observing or collecting information · Study reference: NL-OMON57543

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Start (reported date)
2025-08-14

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 to 99 · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: Not reported

Inclusion criteria: Cases: - Incident Parkinson's disease; o Defined as <=1 month since diagnosis was made by a neurologist in the Netherlands at the moment of recruitment. - Aged >=18 years; - Willing and able to provide informed written or digital consent. Controls: - Assigned an initial DBC code of one of the following specific set of diseases: o A median nerve neuropathy due to entrapment in the carpal tunnel (carpal tunnel syndrome), ulnar nerve neuropathy or compressive peroneal nerve neuropathy which is not related to a trauma or autoimmune disease; o Disc herniation (hernia); o Sciatica; o Lumbago; o Radiculopathy. - Aged >=18 years; - Willing and able to provide informed written or digital consent. Exclusion criteria: Cases: - Initially diagnosed in a non-participating centre and referred to one of the participating hospitals for follow-up care or a second opinion. - Other neurodegenerative diseases (e.g. atypical parkinsonism, ALS, or a  dementia subtype which is not related to PD). Controls: - Diagnosed with Parkinson's disease at the time of inclusion; - Blood relative or spouse of a case selected by the same department of neurology to prevent over matching; - Initially diagnosed elsewhere and referred to one of the participating hospitals for follow-up care or a second opinion; - Other neurodegenerative diseases (e.g. atypical parkinsonism, ALS, dementia) at time of inclusion.
Full study name & original research details

Official study title

Parkinson-PEST: Preventing Emergence of Symptoms by environmental Toxicants identification - PD-PEST

Short title used by the registry

Parkinson-PEST: Preventing Emergence of Symptoms by environmental Toxicants identification

Original description

Intervention: N.A. Primary outcome: The main study parameter is the difference in lifetime exposure to pesticides between cases and controls. Lifetime exposure will be estimated using complementary modalities that focus on occupational, residential, and household exposure. Exposure will be assessed using three complementary modalities: questionnaires, existing databases (residential history from the ‘personal records database’ and pesticide use database), and measurements (blood, saliva, hair, faeces, and via silicone wristbands). Furthermore, the study design allows assessment of other external factors that may be associated with the risk of PD. We will specifically quantify exposure to the following three groups of other external factors: heavy metals, solvents, and air pollution. If other potential risk factors of PD emerge during the study, we intend to also assess exposure to those factors by leveraging materials that have already been collected at baseline (if applicable) in order to answer future questions. Additionally, clinical progression of cases will be serially assessed for 36 months using an annual follow-up questionnaire. In the Nijmegen region, we will expand annual follow-up by using silicone wristbands and wrist-based sensors to assess exposure and clinical progression, respectively. Wrist-based sensors will also be worn in the Leiden region. Secondary outcome: See above.

Conditions reported: Parkinson's disease Parkinson's disease;10028037

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
N.A.
Phases
NA
Sponsor
Radboud Universitair Medisch Centrum
Start date reported by registry
2025-08-14 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

J.S. Bogers · (0)24 361 33 92 · jolien.bogers@radboudumc.nl

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Netherlands

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.