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Detailed brain scans over time

This study uses high-strength magnetic resonance imaging to follow the course of Parkinson's.

Learning by observing or collecting information · Study reference: NL-OMON54720

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported date)
2019-07-02

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 to 99 · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: Not reported

Inclusion criteria: Inclusion criteria for Parkinson's disease patients: -18 years of age or older. -Recently diagnosed idiopathic Parkinson's Disease according to the UK Brain Bank Criteria (<=3 year after diagnosis)., Inclusion criteria for healthy controls: -The age and sex of healthy control subjects should not significantly differ from the age and sex of the PD patients Exclusion criteria: Exclusion criteria for all subjects: -Subjects with contra-indications for a MRI scan as defined in the MRI screenings form of Scannexus (Appendix E), such as claustrophobia or subjects carrying incompatible metallic devices such as pacemakers and certain mechanical valves. -Advanced cognitive impairment (MoCA <24) or dementia according to the DSM V criteria at baseline. -Subjects with other neurodegenerative diseases.
Full study name & original research details

Official study title

Longitudinal ultra-high field imaging in Parkinson*s Disease: Tracking the disease course - TRACK-PD

Short title used by the registry

Longitudinal ultra-high field imaging in Parkinson*s Disease: Tracking the disease course

Original description

Primary outcome: The main study endpoint will be the structural and functional changes of the PD brain as compared to HC, which will be assessed on 7T ultra-high field MR images. We will also use quantitative MRI approaches, since this enables us to detect small structural and anatomical differences which cannot be detected on qualitative MRI acquisitions. Our aim is to create a diagnostic tool, based on MRI characteristics, which can distinguish PD patients from HC. Secondary outcome: A secondary study endpoint will be the detection of differences in imaging characteristics between clinically dissimilar subtypes of PD. We aim to correlate clinical phenotype, genetic characteristics and progression of symptoms to functional and structural MRI variations. This requires a longitudinal follow-up, which enables us to establish in what manner progression of clinical symptoms is related to certain neuroimaging characteristics. Furthermore, our aim is to develop a patient specific prognostic model based on MRI characteristics, which can (partially) predict the disease course for the individual patient. Moreover, we aim to assess the potential of brain-enriched EV miRNAs in blood to distinguish PD from the healthy population.

Conditions reported: Parkinson's disease;10028037

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Not reported
Phases
Not reported
Sponsor
Universiteit Maastricht
Start date reported by registry
2019-07-02 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Netherlands

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.