A pilot study of donor gut microbes

Inclusion criteria: - Clinical diagnosis of idiopathic PD according to UK Brain Bank criteria - PD disease duration of at least five years. - Use of levodopa. - Presence of motor complications (motor fluctuations or dyskinesias), despite adequate PD medication and regardless of severity. - Written informed consent. Exclusion criteria: - Hoehn and Yahr scale stage 5 (most severe stage in scale for severity of PD motor symptoms). - Comorbidity or condition impairing ability to participate in the study according to the investigators. - Current use of probiotics or in the previous three months. - Unstable PD with change in type or dose of PD medication in the previous three months. - Symptoms of a GI infection during the previous three months. - Current need of antibiotics or use in the previous three months. - Current GI malignancy or in the previous six months. - Known obstructions, paralysis or severe motility problems of the gastrointestinal tract, or severe dysphagia with incapability of swallowing 2 liters of macrogol + electrolytes, or inability to receive oral feeding. - Known diagnosis of Inflammatory Bowel Disease (IBD) or celiac disease. - Intestinal resection in medical history. - Recent intraabdominal surgery(< 3 months). - Platelet count < 70x10^9/L - Participation in another study within 16 weeks of screening visit. - Known severe food allergy or allergy to medication that a donor could have used (intake may lead to a life threatening situation). - Immunocompromised state. - Current use of immunosuppressants or opiates, or in the previous month. - For women with child-bearing potential: Pregnancy; current wish to be pregnant or absence of contraception; lactation. - Impaired ability to understand the study content and to give written informed consent. - Unwilling or not capable to comply with the study requirements. - Inability to communicate in Dutch. - Inability to visit the LUMC.