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Sleeping with the head end of the bed raised

Researchers are studying tilted sleeping positions for blood-pressure changes and night-time urination in Parkinson's.

Testing a treatment or activity · Study reference: NL-OMON51733

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported date)
2023-01-18

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

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Who can join?

Ages 18 to 99 · Ask the team who can join

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Read all the rules for taking part

Sex eligibility reported by registry: Not reported

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Orthostatic hypotension defined as a systolic BP decrease of >=20 mmHg, or a diastolic decrease of >=10 mmHg, within 3 min after changing from a supine to standing position OR mean standing BP of = 30 mmHg is required. 2. Orthostatic intolerance: direct complants (dizziness, tunnel- or blurry vision etc.) and/or inirect signs (falls or freezing episodes that relate to postual challenge) 3. Supine hypertension defined as a systolic BP of >=140 mmHg, and/or diastolic of >=90 mmHg, after 5 min of supine rest. 4. Idiopathic PD. 5. Ability to walk (with or without a walking aid). 6. Stable medication regimens for orthostatic hypotension and supine hypertension. Exclusion criteria: Cognitively unable to follow instructions or to fill out questionnaires as judged by the researcher
Full study name & original research details

Official study title

The HEADS-Up Trial: Sleeping in a head-up tilt position to treat orthostatic hypotension, supine hypertension and nocturia in Parkinson's disease - HEADs UP

Short title used by the registry

The HEADS-Up Trial: Sleeping in a head-up tilt position to treat orthostatic hypotension, supine hypertension and nocturia in Parkinson's disease

Original description

Intervention: All participants will sleep in whole-body head-up tilt (HUTS) in three angles for two weeks (6°, 12° and 18° for the intervention group; 1°, 6° and 12° for control groups). The 1° condition in the control group is considered the control intervention. and each angle is preceded by a week ofof the HUTS sleeping position is The intervention period is preceded by a week of horizontal sleeping used for baseline measurements in both groups. The materials used to tilt the bed are personalized to the specific situation of the patient (i.e. double or single matrass) and the patient is guided by a home visit and (bi)weekly video visits by the researcher. When necesary, additional home visits are scheduled. When an increased angle is no longer tolerable, the patient is asked to return to the former angle according to the study protocol.. Primary outcome: Overnight blood pressure (BP) from 24-hour ABPM between patients and controls Secondary outcome: Secondary endpoints include: daily supine blood pressure, orthostatic blood pressure, orthostatic tolerance (complaints of orthostatic hypotension), nocturia, PD motor- and non-motor symptoms, physical activity during the day, falls and subjective comfort of HUTS.

Conditions reported: Parkinson Parkinson's disease;10028037

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
All participants will sleep in whole-body head-up tilt (HUTS) in three angles for two weeks (6°, 12° and 18° for the intervention group; 1°, 6° and 12° for control groups). The 1° condition in the control group is considered the control intervention. and each angle is preceded by a week ofof the HUTS sleeping position is The intervention period is preceded by a week of horizontal sleeping used for baseline measurements in both groups. The materials used to tilt the bed are personalized to the specific situation of the patient (i.e. double or single matrass) and the patient is guided by a home visit and (bi)weekly video visits by the researcher. When necesary, additional home visits are scheduled. When an increased angle is no longer tolerable, the patient is asked to return to the former angle according to the study protocol..
Phases
2
Sponsor
Radboud Universitair Medisch Centrum
Start date reported by registry
2023-01-18 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

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Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Netherlands

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.