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Following thinking changes after a Parkinson's diagnosis

This study combines assessments and brain scans to understand changes in thinking early in Parkinson's.

Learning by observing or collecting information · Study reference: NL-OMON50521

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date)
2017-10-09

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 to 99 · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: Not reported

Inclusion criteria: - Diagnosis Parkinson's disease - Disease duration < 3 months, measured after time of diagnosis. - Willingness to cooperate and sign written informed consent Exclusion criteria: All subjects: - The refusal to be informed about an unforeseen clinical finding, Exclusion from PET:, - Pregnant or breast feeding women, Exclusion from MRI scan:, - MR incompatible implants in the body (e.g. prosthesis, pacemakers, implanted heart valves). - Any risk of having metal particles in the eyes due to manual work without proper eye protections - Tattoos containing red pigments that form a safety risk
Full study name & original research details

Official study title

The Dutch Parkinson and Cognition Study (DUPARC): A prospective study on cognitive pathology in de novo Parkinson*s disease - The Dutch Parkinson and Cognition Study

Short title used by the registry

The Dutch Parkinson and Cognition Study (DUPARC): A prospective study on cognitive pathology in de novo Parkinson*s disease

Original description

Intervention: Geen Primary outcome: The primary endpoints will be the change in FEOBV activity and the change in cognitive functioning between baseline and 3 years of follow-up. Cognitive functioning is measured by an extensive neuropsychological assessment, covering all cognitive domains. Secondary outcome: The secondary endpoints will be: - F-DOPA uptake as a measure of dopaminergic innervation. - Retinal evaluation using OCT technology - Functional connectivity using fMRI resting state - Neuropsychological assessment, including questionnaires - Systemic inflammation - Screening Array (GSA-MD) and/or whole-gene sequencing of the GBA1 gene. - GCase activity

Conditions reported: Parkinson's disease Parkinson's;10028037

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Geen
Phases
NA
Sponsor
Universitair Medisch Centrum Groningen
Start date reported by registry
2017-10-09 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

S.K Meles · (050) 361 35 00 · info@puntvoorparkinson.nl

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Facility not reported

Netherlands

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.