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Steered or ring-shaped deep brain stimulation

This study compares ways of directing stimulation and follows effects in advanced Parkinson's.

Testing a treatment or activity · Study reference: NL-OMON22973

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported date)
2017-12-13

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age range not listed · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: Not reported

Inclusion criteria: Age ≥ 18 years bilaterally implanted with the Boston Scientific® Vercise™ system in the STN for idiopathic Parkinson’s Disease at least 6 months previous to study enrollment the optimal ring-mode stimulation setting has been found for the patient: changing settings will either (a) not improve the motor scores or (b) cause stimulation-induced side-effects Patients who have received this system by participating in the GALAXY-trial can only be randomized after completion of the GALAXY trial. Exclusion criteria: no adequate stimulation response in ring-mode on one of the steerable levels (second and third contact point on each lead) Legally incompetent adults Active psychosis No written informed consent
Full study name & original research details

Official study title

Randomized trial comparing steered stimulation DBS with ring-shaped DBS for advanced Parkinson’s disease

Original description

Intervention: After a period of searching for the optimal steered mode settings, patients will be randomized to receive both steered and ring-mode stimulation in consecutive periods of two months in random order. The patient, the assessor and the investigator performing the statistical analyses will be blind to the order in which the two settings are administered. Primary outcome: We will evaluate the difference of motor symptoms in patients with steered and ring-mode DBS in standardized OFF-drug phase measured with the Movement Disorders Society Unified Parkinson Disease Rating Scale motor evaluation (MDS-UPDRS-ME). Secondary outcome: Secondary outcome consists of symptom scales, used stimulation settings, medication use, stimulation-induced side-effects, activities of daily living scales and a quality of life questionnaire. At the end of the trial, patients will be asked to choose between the two used programs to evaluate which one was perceived as the best. A sub-analysis will be performed to evaluate whether good DBS responders and suboptimal DBS responders score differently on primary and secondary endpoints.

Conditions reported: Parkinson's Disease Deep Brain Stimulation Subthalamic Nucleus (STN) Steering Ziekte van Parkinson Diepe Hersenstimulatie Nucleus Subthalamicus

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
After a period of searching for the optimal steered mode settings, patients will be randomized to receive both steered and ring-mode stimulation in consecutive periods of two months in random order. The patient, the assessor and the investigator performing the statistical analyses will be blind to the order in which the two settings are administered.
Phases
Not reported
Sponsor
Academic Medical Center Amsterdam (AMC)
Start date reported by registry
2017-12-13 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

T.R. ten Brinke · 020 566 3447 · t.r.tenbrinke@amc.uva.nl

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

No locations reported. Ask the study team where participation is available.

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.