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Recording brain activity at different stimulation settings

Researchers are measuring magnetic signals from the brain in people with Parkinson's who have deep brain stimulation.

Testing a treatment or activity · Study reference: NL-OMON19892

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Start (reported date)
2017-08-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age range not listed · Ask the team who can join

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: Not reported

Inclusion criteria: -Having undergone STN-DBS placement for PD six months or longer before MEG registrations; -Age ¡Ý 18 years; -Monopolar stimulation -Pre-operative DTI data available and of sufficient quality. -Post-operative NPO is available and was performed in the same DBS settings as during the MEG recordings. Exclusion criteria: -Hoehn and Yahr stage higher than 3, as determined in the DBS ON- (but medication OFF-)state. -Anatomical deformities that prevent the subject from undergoing an MEG registration in supine position (i.e. thoracic kyphosis); -Continuous intrajejunal levodopa or subcutaneous apomorphine infusion in addition to DBS; -Dementia according to the Movement Disorder Society criteria for PD with dementia. -Conditions that will cause excessive MEG artefacts (other than the DBS electrode and stimulator). -A history of stroke or major vascular lesions on brain MRI; -A history of major traumatic brain injury; -Peri-operative intracerebral complications (e.g. bleeding or infection) related to STN-DBS placement inflicting permanent changes;
Full study name & original research details

Official study title

Functional brain network changes as indicators of deep brain stimulation-induced cognitive and psychiatric side effects in Parkinson¡¯s disease related to electrode contacts: a proof of concept study.

Short title used by the registry

MEG in Parkinson¡¯s disease patients with DBS

Original description

Intervention: In each subject, eleven MEG recordings of 5 minutes duration will be completed in a single session. The first MEG recording will be performed in the optimal DBS settings of the participant. After this, nine MEG recordings will take place using different DBS settings in a randomized order: during eight recordings in turn unilateral stimulation of each of the individual contact points takes place and one recording will be performed in the DBS-OFF state. Primary outcome: Stimulation site-specific neurophysiological measures, as obtained by MEG recordings, and differences in the exact locations and structural connections of each contact point, as obtained by brain imaging. -Correlation of neurophysiological- and structural data to clinical measures of non-motor symptoms (both pre- and post-DBS), obtained in the context of standard clinical care and clinical studies. Secondary outcome: MDS-UPDRS III-ratings are scored on a regular basis as part of clinical care and can be correlated to the functional and structural networks as well.

Conditions reported: Parkinson's disease, Deep Brain Stimulation

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
In each subject, eleven MEG recordings of 5 minutes duration will be completed in a single session. The first MEG recording will be performed in the optimal DBS settings of the participant. After this, nine MEG recordings will take place using different DBS settings in a randomized order: during eight recordings in turn unilateral stimulation of each of the individual contact points takes place and one recording will be performed in the DBS-OFF state.
Phases
Not reported
Sponsor
VU medical center
Start date reported by registry
2017-08-01 (reported)

Registry updated: Not reported · Status last verified by the registry submitter: Not reported

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

H.W. Berendse · +31 204442830 · h.berendse@vumc.nl

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

No locations reported. Ask the study team where participation is available.

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.