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Exercise after brain stimulation surgery

This study examines how physical activity relates to the course of Parkinson’s in people who already have an implanted brain stimulator.

Testing a treatment or activity · Study reference: NCT07838636

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Who can join?

Ages 50 years to 70 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Patients diagnosed with idiopathic Parkinson's disease (ICD-10:G20). * Patients qualified for advanced therapies using DBS-STN. * Grade II-IV on the Hoehn \& Yahr scale. * Age 50-70. * Consent to participate in the study. Exclusion Criteria: * Patients diagnosed with atypical parkinsonism. * Patients not eligible for advanced therapies with DBS-STN. * Hoehn \& Yahr Grade I and V. * Age \<50 and \>70 * Patients diagnosed with dementia syndrome (MMSE \< 24/30). * Diseases of the osteoarticular system and muscles that make it impossible to undergo rehabilitation. * Severe kidney, liver and heart failure. * Active malignancy or malignancy diagnosed and treated within 3 years prior to the study.
Full study name & original research details

Official study title

Effect of Physical Activity on the Course of Parkinson's Disease in Patients With Bilateral DBS-STN Stimulation - a Randomized Controlled Trial.

Short title used by the registry

Effect of Physical Activity on the Course of Parkinson's Disease in Patients With Bilateral DBS-STN Stimulation.

Original description

Parkinson's disease is a common, progressive neurodegenerative disorder. The degeneration of dopaminergic neurons is associated with characteristic clinical symptoms such as tremor, rigidity, slowness of movement (bradykinesia) and postural instability. Subthalamic nucleus deep brain stimulation (DBS-STN) is a recognized and widely used method of treating advanced stages of Parkinson's disease. It improves clinical symptoms such as tremor, rigidity and slowness of movement (bradykinesia). This method has limited application for late motor and non-motor symptoms such as: akinesia, postural instability, gait, including the phenomenon of "freezing", recurrent falls, balance and dysarthria. These symptoms reduce the quality of life of patients and make them dependent on their caregivers. There is a clear need to develop additional forms of therapy that complement deep brain stimulation in controlling late motor and non-motor symptoms. Physical activity is a commonly used and recommended form of therapy for patients with Parkinson's disease and a complement to pharmacological therapy, improving gait, balance and quality of life. However, there are no clear recommendations including patients after implantation of DBS-STN stimulators to the group undergoing physiotherapy. To this day, only one clinical trial has been registered assessing the effect of physiotherapy on balance and gait in patients with DBS-STN.

Conditions reported: Parkinson Disease; Deep Brain Stimulation; PD - Parkinson&#39;s Disease; PD; DBS

Study type
Interventional
Interventions
Physiotherapy; Education about physiotherapy
Phases
NA
Sponsor
Medical University of Warsaw
Start date reported by registry
2024-09-05 (actual)

Registry updated: 2026-10-06 · Status last verified by the registry submitter: 2026-06

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Marta M Betka, PhD student · 48798789277 · marta.maria.betka@gmail.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Department of Neurology, Faculty of Health Sciences, Bródnowski Mazovian Hospital

Warsaw, Poland

Recruiting

prof. dr hab. n. med. Dariusz Koziorowski · (0-22) 326 57 44 · neurologia@szpital-brodnowski.waw.pl

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.