Recruiting · registry status

Comparing detailed brain scans in people with early warning signs

Researchers compare high-detail and standard brain scans in people being studied for signs that can appear before a Parkinson’s diagnosis.

Testing a treatment or activity · Study reference: NCT07809438

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

Who can join?

Age 18 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1. Prodromal participant enrolled in the PPMI 015 sub study. 2. Able to provide consent. Exclusion Criteria: a) Any medical or psychiatric condition or lab abnormality that precludes participation per investigators judgement.

Full study name & original research details

Official study title

A Comparative Performance Study Between High and Standard Resolution Positron Emission Tomography (PET) Camera Using [18F]AV-133 in Prodromal Parkinson's Disease [Dual PET AV133 in Prodromal PD]

Short title used by the registry

A Comparative Performance Study Between High and Standard Resolution Positron Emission Tomography Camera Using [18F] AV-133 in Prodromal Parkinson's Disease

Original description

This study is a single-center, longitudinal study and will be conducted at the Institute for Neurodegenerative (INDD) Site in New Haven, CT. This study aims to recruit participants from the ongoing Parkinson's Progression Markers Initiative AV-133 Prodromal Imaging sub study \[PPMI 015\] to obtain a second comparison imaging scan. In addition to being imaged with the standard Positron Emission Tomography (PET) camera after the \[18F\]AV133 injection in the PPMI 015 sub study, participants agreeing to a second scan will be imaged with the NeuroEXPLORER (NX) PET camera per this protocol. This study will enroll approximately 25 participants at the INDD site. The dual PET scans will be completed at baseline, 1-and 2- years follow up. Participants may be asked to undergo further longitudinal scans based on the acquired study data. All participants will have longitudinal clinical, biomarker, and genetic data for correlation analyses to imaging data from the PPMI Clinical study.

Conditions reported: Prodromal Parkinson's Disease

Study type: Interventional
Interventions: [18F] AV-133 PET Imaging
Phases: PHASE2
Sponsor: Michael J. Fox Foundation for Parkinson's Research
Start date reported by registry: 2025-09-18 (actual)

Registry updated: 2026-09-09 · Status last verified by the registry submitter: 2026-09

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Lianne Ramia · 203-590-5600 · LRamia1@indd.org

Jessica Dimos · 203-590-5600 · jdimos@indd.org

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Institute for Neurodegenerative Disorders

New Haven, Connecticut, United States

Recruiting

Mackenzee George Clinical Research Coordinator II · 475-318-8248 · mgeorge@xingimaging.com

Kristen Hagwell Clinical Research Nurse II, RN · 475-318-8259 · khagwell@xingimaging.com

Neha Prakash, MBBS

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.