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Donating samples for research into inherited and age-related brain conditions

Researchers collect blood, genetic material and family-history information to support research into conditions affecting brain cells.

Learning by observing or collecting information · Study reference: NCT07798700

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

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Looking for volunteers

Start (reported actual date)
2025-12-12
Main measurements finished (planned)
2070-01-01
Study finished (planned)
2070-01-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 18 years and over · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1. People with a clinical diagnosis of a neurodegenerative disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), primary progressive aphasia (PPA), limbic-predominant age-related TDP-43 encephalopathy (LATE), corticobasal syndrome (CBS), posterior cortical atrophy (PCA), primary lateral sclerosis (PLS), primary muscular atrophy (PMA), or individuals with a suspected neurodegenerative dementia and/or movement disorder of unknown etiology will be considered for enrollment 2. Family Members of individuals who meet the criteria of group 1, who are people who may or may not be at risk for a similar neurodegenerative disease, who may or may not be symptomatic, and who may or may not have known or unknown genetic risk. 3. People with no known neurological disease who will provide control data. Exclusion Criteria: 1. Anyone who is under the age of 18. 2. Anyone with a condition or in a situation which, in the investigator's opinion, could confound the study findings or may interfere significantly with a person's participation, including but not limited to neurological, psychological, and other medical conditions (such as cardiac, neurosurgical, infectious conditions).
Full study name & original research details

Official study title

Biofluid Research on Age-Related or Inherited Neurodegeneration (BRAIN)

Short title used by the registry

Biofluid Research on Age-Related or Inherited Neurodegeneration

Original description

The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with age-related neurodegenerative conditions, or their family members who may or may not be at risk for similar conditions. This study will continue to further expand research into the molecular and genetic basis of these diseases and their risk factors.

Conditions reported: Frontotemporal Degeneration (FTD); ALS (Amyotrophic Lateral Sclerosis); Primary Progressive Aphasia (PPA); Familial Frontotemporal Lobar Degeneration (fFTLD); Fronto-temporal Lobar Dementia; Dementia With Lewy Bodies (DLB); Cortical Basal Syndrome (CBS); Alzheimer's Disease (AD); Progressive Supranuclear Palsy(PSP); Parkinson's Disease (PD); Parkinson's Disease Dementia (PDD); Limbic-predominant Age-related TDP-43 Encephalopathy (LATE); Posterior Cortical Atrophy (PCA); Primary Lateral Sclerosis (PLS); Primary Muscular Atrophy (PMA)

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Not reported
Phases
Not reported
Sponsor
University of Pennsylvania
Start date reported by registry
2025-12-12 (actual)

Registry updated: 2026-09-01 · Status last verified by the registry submitter: 2026-08

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Cara Joyce, MPH · 267-271-0740 · cara.joyce@pennmedicine.upenn.edu

Emily Xie · 16109553114 · emily.xie@pennmedicine.upenn.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Recruiting

Cara Joyce, MPH · 267-271-0740 · cara.joyce@pennmedicine.upenn.edu

Emily Xie · emily.xie@pennmedicine.upenn.edu

Corey McMillan, PhD

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.