Recruiting · registry status

Comparing brain areas for a stimulation treatment

Researchers compare the effects of aiming a brain stimulation method at different targets in people with Parkinson’s.

Testing a treatment or activity · Study reference: NCT07745673

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported actual date): 2026-06-29
Main measurements finished (planned): 2027-01-31
Study finished (planned): 2027-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 40 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1. Adult males or females aged ≥40 years; 2. Diagnosis of idiopathic Parkinson's disease according to the UK Brain Bank criteria, with age of onset ≥40 years; 3. Previous or current treatment with dopamine replacement therapy (e.g., levodopa) with good response; 4. Hoehn and Yahr (H\&Y) stage 1.5-2.5; 5. Able to walk independently for at least 5 minutes without assistive devices; 6. No severe freezing of gait (FOG); 7. Disease duration ≥2 years since diagnosis, clinically stable, and able to comply with study assessments and interventions; 8. Stable medication regimen for at least 4 weeks prior to the study; 9. Signed informed consent form; subject or legal guardian is able to understand and willing to participate in this study. Exclusion Criteria: 1. Presence of other neurological disorders that may affect the study (e.g., ...); 2. Mild cognitive impairment or above (MoCA ≤23); 3. Orthopedic or other medical conditions that may affect gait or balance; 4. Contraindications to MRI, such as claustrophobia; 5. History of antipsychotic, antidepressant, or other medications that may affect dopamine levels; 6. History of other severe psychiatric disorders; 7. History of epilepsy, traumatic brain injury, or implanted metallic devices in the brain or heart (e.g., stimulators, pacemakers) or other contraindications; 8. History of electroconvulsive therapy (ECT); 9. Currently participating in other gait- or balance-related intervention training; 10. Physician-diagnosed cardiovascular risk factors for exercise.

Full study name & original research details

Official study title

Comparative Efficacy of Temporal Interference Stimulation at Different Targets in Parkinson's Disease

Short title used by the registry

Comparative Study of TIS Efficacy Across Different Targets

Original description

This prospective, randomized, participant- and outcome-assessor-blinded, parallel-group exploratory trial will compare the target-dependent clinical, neuroimaging, and electrophysiological effects of temporal interference stimulation (TIS) targeting the subthalamic nucleus (STN) or globus pallidus internus (GPi) in patients with Parkinson's disease (PD). Eighteen participants with idiopathic PD will be randomly assigned in a 1:1 ratio to the STN-TIS or GPi-TIS group. Participants will receive one 20-minute TIS session daily for 7 consecutive days. Motor symptoms will be assessed using the MDS-UPDRS Part III immediately before and after each daily stimulation session. Resting-state functional magnetic resonance imaging (fMRI) and 64-channel electroencephalography (EEG) will be performed before the first stimulation session and immediately after completion of the 7-day intervention. The primary outcomes are: (1) change in MDS-UPDRS Part III score from Day 1 before stimulation to Day 7 after stimulation; and (2) changes in regional spontaneous brain activity and seed-based functional connectivity measured using resting-state fMRI. Secondary outcomes are: (1) daily immediate changes in MDS-UPDRS Part III scores and the proportion of participants achieving at least 30% improvement at Day 7; and (2) changes in resting-state 64-channel EEG relative bandpower. Safety and tolerability will be evaluated by monitoring adverse events and local skin reactions throughout the intervention. This study aims to provide preliminary evidence regarding target-dependent functional response patterns associated with STN- and GPi-targeted TIS in PD.

Conditions reported: PARKINSON DIS

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07745673 ↗ — RECRUITING; checked 2026-10-11
ClinicalTrials.gov · NCT07745673 ↗ — Recruiting; WHO ICTRP processed 2026-08-10; checked 2026-10-11

Study type: Interventional
Interventions: TIS-STN; TIS-GP
Phases: NA
Sponsor: Zhongnan Hospital
Start date reported by registry: 2026-06-29 (actual)

Registry updated: 2026-08-04 · Status last verified by the registry submitter: 2026-07

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Yang Pan · 13952098253 · panyang.zn@whu.edu.cn

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, China

Recruiting

Bin Mei · 02767812787 · znyyll@126.com

Facility not reported

China

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.