Recruiting · registry status

Testing supervised brain stimulation at home

Researchers are testing a home brain stimulation approach with remote supervision, looking at safety and changes in slow movement, stiffness and walking.

Testing a treatment or activity · Study reference: NCT07518290

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

Who can join?

Ages 40 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Diagnosis of Parkinson's disease according to established clinical criteria * Mild-to-moderate disease severity, defined as Hoehn and Yahr stage 1.5-3; * Age between 40 and 80 years; * Stable anti-parkinsonian medication regimen; * Ability to walk unaided for at least 2 minutes. Exclusion Criteria: * contraindications to TIs (e.g., metal implantation, pacemakers, etc.); * the use of DBS; * significant cognitive impairment as defined by the diagnosis of Alzheimer's disease or dementia, or Montreal Cognitive Assessment (MoCA) total score\<21, a recommended threshold for dementia in PD; * diagnosis of other neurological conditions such as multiple sclerosis, previous stroke; * report of severe lower-extremity arthritis, pain, or orthopedic problems significantly affecting gait; * physician-diagnosis of schizophrenia or other psychiatric illness; * an unwillingness to cooperate or participate in the study protocol. Eligible and interested participants will then be enrolled and complete baseline assessments before the randomization.

Full study name & original research details

Official study title

Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease: Protocol For a Double Blind Randomized Controlled Trial

Short title used by the registry

Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease

Original description

The goal of this clinical trial is to learn if home-based temporal interference stimulation (TIS) works to improve motor symptoms in people with Parkinson's disease (PD). It will also learn about the safety of this treatment. The main questions it aims to answer are: 1. Does home-based TIS improve movement problems such as slow movement, stiffness, and walking difficulty? 2. Are the effects maintained after the treatment ends? 3. What medical problems (adverse events) occur during treatment? Researchers will compare active TIS to a sham treatment (a look-alike procedure that does not deliver active stimulation) to see if TIS works. Participants will: 1. Receive active TIS or sham stimulation once a day for 4 weeks at home under remote supervision 2. Visit the clinic at specific time points for movement assessments 3. Complete online questionnaires about symptoms and quality of life

Conditions reported: PARKINSON DISEASE (Disorder); Motor Symptoms

Study type: Interventional
Interventions: Home-based Transcranial Temporal Interference Stimulation (HB-TIS)
Phases: NA
Sponsor: Shanghai University of Sport
Start date reported by registry: 2026-04-04 (actual)

Registry updated: 2026-09-22 · Status last verified by the registry submitter: 2026-09

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Yu Liu, Prof. · +86 21 65507351 · yuliu@sus.edu.cn

Zijun Lu · +86 21 65507862 · luzijun@snnu.edu.cn

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Shanghai University of Sport

Shanghai, Shanghai Municipality, China

Not yet recruiting

Zijun Lu · +86 21 65507862 · luzijun@snnu.edu.cn

Shanghai University of Sport

Shanghai, Shanghai Municipality, China

Recruiting

Zijun Lu · +86 21 65507862 · luzijun@snnu.edu.cn

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.