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Checking the safety of Lu AF28996

Researchers study how people with Parkinson’s tolerate this study medicine and how the body handles it.

Testing a treatment or activity · Study reference: NCT07513441

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date)
2026-05-26
Main measurements finished (planned)
2027-05-31
Study finished (planned)
2027-05-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 35 years to 85 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Key Inclusion Criteria: * The participant is Chinese, defined as having four Chinese grandparents being born in China. * The participant is diagnosed with idiopathic Parkinson's disease (consistent with the United Kingdom PD Society Brain Bank Criteria for the Diagnosis of PD). * The participant's Modified Hoehn and Yahr score is ≥2 and ≤4 (in OFF) and ≤3 in the ON state. * The participant experiences well recognizable and predictable motor fluctuations in the awake time including predictable morning OFF episodes causing clinically significant disability during the last 3 months prior to screening, as evaluated by the investigator. Key Exclusion Criteria: * The participant has received oral or transdermal dopamine agonist treatment ≤4 weeks prior to screening. * The participant has undergone a neurosurgical intervention for Parkinson's disease (such as pallidotomy, thalamotomy, foetal or stem cell transplantation or deep brain stimulation). * The participant has any other disorder for which the treatment takes priority over treatment of Parkinson's disease or is likely to interfere with trial treatment or impair treatment compliance. * The participant has received Traditional Chinese Medicine treatment ≤4 weeks prior to screening. Note: Other protocol-defined inclusion and exclusion criteria may apply.
Full study name & original research details

Official study title

Interventional, Open-label, Trial Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Lu AF28996 in Chinese Men and Women With Parkinson's Disease

Short title used by the registry

A Trial of Lu AF28996 in Participants With Parkinson's Disease (PD)

Original description

The purpose of this study is to investigate the safety of Lu AF28996, how well it is tolerated and what the body does to the drug in participants with Parkinson's disease.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Lu AF28996
Phases
PHASE1
Sponsor
H. Lundbeck A/S
Start date reported by registry
2026-05-26 (actual)

Registry updated: 2026-08-10 · Status last verified by the registry submitter: 2026-08

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Email contact via H. Lundbeck A/S · +45 36301311 · HQ_Medinfo@Lundbeck.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Beijing TiantanHospital, CapitalMedical University

Beijing, Beijing Municipality, China

Recruiting

Xuanwu Hospital Capital Medical University

Beijing, Beijing Municipality, China

Recruiting

Fudan University - Huashan Hospital - Institute of Urology

Shanghai Shi, Shanghai Municipality, China

Recruiting

West China Hospital, Sichuan University

Chengdu, Sichuan, China

Recruiting

Facility not reported

China

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.