Recruiting · registry status

How aerobic exercise affects brain blood flow, thinking and walking

Researchers test a supervised exercise programme and measure circulation, thinking and walking in Parkinson’s.

Testing a treatment or activity · Study reference: NCT07478146

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date): 2026-02-28
Main measurements finished (planned): 2027-06-30
Study finished (planned): 2027-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 40 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Clinical diagnosis of Parkinson's disease * Hoehn \& Yahr stages 1-3 * Stable antiparkinsonian medication for at least 4 weeks * Montreal Cognitive Assessment (MoCA) score ≥ 18 * Ability to walk independently (with or without assistive device) * Medical clearance for participation in moderate-intensity exercise Exclusion Criteria: * Change in medication * Contraindication to exercise

Full study name & original research details

Official study title

Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial

Short title used by the registry

Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease

Original description

This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.

Further description from the registry

This is a parallel-group randomized controlled trial Participants (n=40) diagnosed with Parkinson's disease, stages 1-3 on Hoehn \& Yahr scale, will be randomly allocated (1:1 block randomization) to: * Aerobic Training Group; * Control Group (usual care) The intervention will last 12 weeks, 3 sessions/week Pre and post-intervention assessments will include: * Cerebrovascular function: neurovascular coupling, cerebrovascular reactivity (breath-holding index), dynamic cerebral autoregulation (transfer function analysis), and acute cerebral blood flow response to exercise (transcranial Doppler; vertebral artery flow during silent reading). * Peripheral vascular and cardiovascular function: brachial artery flow-mediated dilation, carotid intima-media thickness, resting blood pressure, resting heart rate, cardiorespiratory fitness (VO₂peak), heart rate variability (time and frequency domains), and baroreflex sensitivity. * Cognitive performance: Montreal Cognitive Assessment (MoCA), Trail Making Test A and B, and Stroop Color-Word Test. * Gait biomechanics: spatiotemporal parameters, 3D kinematics (Vicon system), and kinetics (force platform). * Clinical and non-motor symptoms: UPDRS, Non-Motor Symptoms Scale (NMSS), sleep quality (PDSS), anxiety (PAS), depressive symptoms (GDS-15), apathy (Apathy Inventory), fatigue (Parkinson Fatigue Scale), pain (Numeric Rating Scale), and quality of life (PDQ-8). * Body composition: quadriceps muscle thickness and subcutaneous adipose tissue thickness assessed by ultrasound. All experimental sessions will be performed in the "on" medication state

Conditions reported: PARKINSON DISEASE (Disorder)

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07478146 ↗ — RECRUITING; checked 2026-10-11
ClinicalTrials.gov · NCT07478146 ↗ — Recruiting; WHO ICTRP processed 2026-04-20; checked 2026-10-11

Study type: Interventional
Interventions: Aerobic training; Usual Care
Phases: NA
Sponsor: Raphael Mendes Ritti Dias
Start date reported by registry: 2026-02-28 (actual)

Registry updated: 2026-04-13 · Status last verified by the registry submitter: 2026-04

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Raphael M Ritti-Dias, PhD · +5519999406878 · raphaelritti@gmail.com

Hélcio Kanegusuku, PhD · +55 11 99539-9557 · helciokng@gmail.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Associação Brasil Parkinson

São Paulo, São Paulo, Brazil

Recruiting

Verônica Souza, MD · +55 11 97445-9125 · veronica.souza82@yahoo.com.br

Facility not reported

Brazil

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.