Recruiting · registry status

Combining movement and thinking exercises

Researchers test a programme that brings together different exercise approaches in people with moderate to advanced Parkinson’s.

Testing a treatment or activity · Study reference: NCT07465107

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date): 2025-03-26
Main measurements finished (planned): 2027-02-14
Study finished (planned): 2027-02-14

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 18 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Diagnosis of PD according to MDS-PD criteria * Aged ≥ 18 years * Informed consent * PD symptoms ≥ 4 years * Independent gait Exclusion Criteria: * Diagnosis of PD Dementia according to the MDS-PD Dementia criteria

Full study name & original research details

Official study title

Motor and Cognitive Exercise in Parkinson's Disease. A Feasibility Randomized Clinical Trial

Short title used by the registry

Motor and Cognitive Exercise in Parkinson's Disease.

Original description

The aim of this study is to examine the effects of a specialized multi-modal intervention in patients with moderate to advanced Parkinson's disease (PD). The hypothesis is that a specialized motor- and cognitive exercise program in addition to usual care can improve gait and balance better than usual care alone. 48 patients with PD and a symptom duration of 4 or more years will be randomized 1:1 to either a control arm or to an intervention arm. The control arm will have usual management of their PD. The intervention arm will receive exercises aimed at both motor and cognitive impairments of PD over the course of 12 weeks. The study has been designed in partnership with the Copenhagen Trial Unit (CTU), Copenhagen Univeristy Hospital, to ensure both internal and external validity. To increase reproducibility, detailed protocols for all training modalities will be shared along with the study results. This study is a feasibility study with the intention of a following international multi-center study to corroborate the results. Both feasibility outcomes for the intervention itself and clinical outcomes for the participants will be published.

Further description from the registry

Intervention: The exercise program will consist of gait and balance training, lower body strength training and dual task training while treadmill walking. The program will include an individualized and progressive exercise program 3 times x 1 hour a week for 12 weeks with the following exercise modalities: 1. Treadmill training for gait and balance training combined with dual task motor cognitive training. 2. Progressive gait and motor-cognitive balance exercises 3. Progressive resistance training including leg press. The program will be conducted under supervision by a physiotherapist or an exercise physiologist. Usual treatment is permitted during the trial, both pharmacological and non-pharmacological. The treatment is preferably stable during the intervention and follow-up, but necessary changes will be registered. All participants will be examined at baseline, after 12 weeks and again 6 and 12 months after baseline.

Conditions reported: Parkinson Disease (PD)

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07465107 ↗ — RECRUITING; checked 2026-10-11
ClinicalTrials.gov · NCT07465107 ↗ — Recruiting; WHO ICTRP processed 2026-03-16; checked 2026-10-11

Study type: Interventional
Interventions: Motor-cognitive exercise; Usual Care
Phases: NA
Sponsor: Annemette Lokkegaard
Start date reported by registry: 2025-03-26 (actual)

Registry updated: 2026-03-11 · Status last verified by the registry submitter: 2026-03

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Annemette Løkkegaard, MD, PhD · +45 38 63 52 48 · annemette.loekkegaard@regionh.dk

Løkkegaard

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Department of Neurology, Bispebjerg and Frederiksberg Hospital

Copenhagen NV, Denmark

Recruiting

Annemette Løkkegaard, MD, PhD · +45 38 63 52 48 · annemette.loekkegaard@regionh.dk

Facility not reported

Denmark

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.