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Testing stimulation for understanding sentences

Researchers study immediate effects of stimulation aimed at a deep brain area on sentence processing and brain connections.

Testing a treatment or activity · Study reference: NCT07449117

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (planned)
2026-03
Main measurements finished (planned)
2027-12
Study finished (planned)
2028-12

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 60 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI). Exclusion Criteria: * Any severe psychiatric disorder. * History of other neurological diseases affecting the central nervous system. * Severe head trauma. * Uncompensated internal or oncological disease. * Presence of MRI-incompatible metal in the body (e.g., pacemaker).
Full study name & original research details

Official study title

Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases

Short title used by the registry

Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Original description

The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.

Further description from the registry

The study aims to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the deep structures of the fronto-striatal circuit involved in language processing. The research focuses on patients with neurodegenerative diseases who often suffer from communication deficits and impaired sentence comprehension. Participants will undergo a cross-over design consisting of a single session of active TIS directed at the striatum and a session of placebo stimulation. The stimulation will be administered in a randomized order. The duration of the stimulation is approximately 20 minutes. During the stimulation, participants will perform a sentence comprehension task. Resting-state fMRI measurements will be taken before and after the stimulation to evaluate offline effects on brain connectivity and potential neuroplasticity.

Conditions reported: Mild Cognitive Impairment (MCI) Amnestic; Lewy Body Disease With Mild Cognitive Impairment; Parkinson's Disease With Mild Cognitive Impairment

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Active Temporal Interference Stimulation (TIS); Placebo / Sham TIS
Phases
NA
Sponsor
Masaryk University
Start date reported by registry
2026-03 (estimated)

Registry updated: 2026-03-04 · Status last verified by the registry submitter: 2026-02

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Ľubomíra Nováková, Ph.D. · +420 549 497 766 · lubomira.novakova@ceitec.muni.cz

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

CEITEC MU (Central European Institute of Technology, Masaryk University)

Brno, South Moravian, Czechia

Recruiting

Ľubomíra Nováková, Ph.D. · +420 549 497 766 · lubomira.novakova@ceitec.muni.cz

Ľubomíra Nováková, Ph.D.

Irena Rektorová, Prof. Ph.D.

Jiří Mekyska, Ph.D.

Jan Fousek, Ph.D.

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.