Recruiting · registry status

How treadmill rehabilitation relates to the gut

Researchers compare treadmill rehabilitation with and without virtual-reality features, studying changes in gut microbes and related measurements in Parkinson’s.

Testing a treatment or activity · Study reference: NCT07434089

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date): 2025-10-20
Main measurements finished (planned): 2027-10-20
Study finished (planned): 2028-10-20

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 40 years to 70 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Diagnosis of PD according to the Movement Disorder Society Clinical * Diagnostic Criteria for Parkinson's Disease * Age comprised between 40 to 70 years * Patients with moderate to advanced disease (2 ≤ Hoehn and Yahr classification grade ≤ 4) * Individuals able to walk independently (FAC \> 2) Exclusion Criteria: * PD patients with (1) weight \> 135 kg and Height \> 200 cm * Open lesions or bandages whether in contact with the harness of C-Mill strumentation * chronic gastro-intestinal (GI) disease including malabsorption; * clinical history of gastric lesions, gastro-resection or major intestinal surgery; * systemic and/or neurologic infectious, inflammatory, or autoimmune diseases of gastro-intestinal (GI) eg. Chron disease; * Acute GI phlogosis or GI disease in the last 4 weeks before recruitment; * Use of domperidone, or any drug potentially affecting gastrointestinal motility and integrity; * Use, in the last 4 weeks preceding the recruitment and until t2, of pre-probiotics or therapy based upon steroids, nonsteroidal anti-inflammatory drugs, antibiotics or antifungals; * anamnesis suggestive of GI cancer pathology.

Full study name & original research details

Official study title

Gut-Brain Axis and Rehabilitation: Study on the Effects of C-Mill Technology on the Intestinal Microbiota of Parkinson's Disease Patients

Short title used by the registry

Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease

Original description

The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with Parkinson's disease. Three groups will be involved: one undergoing conventional physiotherapy, one treated with the C-Mill without virtual reality (VR), and one treated with C-Mill technology combined with VR. Clinical assessments and the collection of biological samples (stool, serum, and plasma) will be carried out at three time points: at baseline, at the end of treatment (21 days), and after 3 months.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07434089 ↗ — RECRUITING; checked 2026-10-13
ClinicalTrials.gov · NCT07434089 ↗ — Recruiting; WHO ICTRP processed 2026-03-02; checked 2026-10-13

Study type: Interventional
Interventions: C-Mill technology treadmill equipped with semi-immersive VR; C-Mill treatment without semi-immersive virtual reality (VR); Conventional physiotherapy training
Phases: NA
Sponsor: IRCCS Centro Neurolesi Bonino Pulejo
Start date reported by registry: 2025-10-20 (actual)

Registry updated: 2026-02-25 · Status last verified by the registry submitter: 2026-02

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

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Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Irccs Centro Neurolesi Bonino Pulejo

Messina, Messina, Italy

Recruiting

Maria Lui · (+39) 09060128163 · maria.lui@irccsme.it

Facility not reported

Italy

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.