Recruiting · registry status

Studying focused ultrasound stimulation for neurological conditions

Researchers are investigating whether low-intensity sound waves aimed at the brain can be used to influence brain activity.

Testing a treatment or activity · Study reference: NCT07417280

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date): 2025-12-02
Main measurements finished (planned): 2035-12-31
Study finished (planned): 2040-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 years to 85 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * 18-85 years of age * Patients diagnosed with neurological disorders, (such as epilepsy, brain tumour, movement disorders) or psychiatric disorders (such as substance abuse disorder) * Patients undergoing medical or surgical treatment (such as DBS) for neurological disorders Exclusion Criteria: * History of stroke * Comorbid dementia * Scored below 22 on the Montreal Cognitive Assessment (MoCA) * Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD) * Presence of metal implanted in body that is contraindicated in TMS/MRI * Pregnancy * Major depression/psychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study * Receiving a psychotropic medication or taking recreational substances that in the opinion of the investigator will significantly affect safety of the protocol * Major systemic illness or infection

Full study name & original research details

Official study title

Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders

Short title used by the registry

LIFUS For Neurological Disorders

Original description

Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation. Studies in healthy subjects have shown that application of LIFUS to the motor region of the brain can mildly decrease neuron excitability in healthy controls. The purpose of the present study is to evaluate the effects of LIFUS on brain tissue excitability in patients with movement disorders in order to elucidate the therapeutic potential of LIFUS.

Conditions reported: Parkinson's Disease (PD); Essential Tremor; Orthostatic Tremor; Dystonia; Epilepsy; Substance Abuse Disorder; Deep Brain Stimulation

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07417280 ↗ — RECRUITING; checked 2026-10-11

Study type: Interventional
Interventions: LIFUS; Sham LIFUS
Phases: NA
Sponsor: University Health Network, Toronto
Start date reported by registry: 2025-12-02 (actual)

Registry updated: 2026-08-13 · Status last verified by the registry submitter: 2026-08

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

No central contact is listed. Check the location contacts or the official registry record.

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Toronto Western Hospital, 399 Bathurst St

Toronto, Ontario, Canada

Recruiting

Alyssa Schleifer · 416-603-5800 · Neurosurgery.Research@uhn.ca

Tasnuva Hoque · 416-603-5800 · Neurosurgery.Research@uhn.ca

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.