Recruiting · registry status

Using brain recordings to choose stimulation settings

Researchers test whether recordings of brain activity can help programme implanted stimulators for Parkinson’s more effectively.

Testing a treatment or activity · Study reference: NCT07348705

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date): 2026-01-15
Main measurements finished (planned): 2027-01-15
Study finished (planned): 2031-01-15

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 21 years to 89 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Patients with a diagnosis of idiopathic PD fulfilling the Movement Disorder Society Clinical Diagnostic Criteria for PD * DBS implantation with the Percept DBS device (Medtronic, USA) for the treatment of motor symptoms * Ability to give informed consent for the study * Willingness to do this study at the time of the initial programming session * Age 21 to 89 years old Exclusion Criteria: * Inability to comply with the study protocol * Atypical Parkinsonism * Any personality or mood symptoms that study personnel believe will interfere with the study requirements

Full study name & original research details

Official study title

Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease

Short title used by the registry

Electrophysiology-based DBS Programming for PD

Original description

Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.

Further description from the registry

Up to thirty patients with DBS (unilateral or bilateral leads) attached to a bidirectional implantable pulse generator will be enrolled in this study. This commercially available IPG allows both therapeutic stimulation and chronic sensing. It has been designed to capture local field potentials (LFPs) from implanted DBS leads while delivering stimulation both inside and outside the clinic. After recording LFP data, then, the physician will perform the traditional clinical monopolar review and determine the optimized DBS settings ('clinician-based' settings) following standard clinical procedures, and without looking at the physiology data. In parallel, the LFP data will be analyzed to identify the 'optimal' therapy contact based on 1) maximum beta power, and 2 ) broad-band multi-frequency analysis. The physician will then setup up to 4 stimulation programs will be set up: 1. Clinician-based programming (standard of care), 2. Maximum Beta power-based programming, 3. Broad-band programming. 4. If needed, second-best clinician-based programming (standard of care) In this study, settings 1, 2, and 4 (optional) are determined based on established standards of care or manufacturer guidelines. Setting 3, however, is derived using our novel electrophysiology-based algorithm. While the method for determining this setting is innovative, the resulting parameter may be identical to those obtained through conventional approaches (settings 1, 2, or 4). Therefore, although the methodology introduces a new process, the final settings remain within clinically accepted ranges and do not exceed standard clinician-based practices.

Conditions reported: Parkinson's Disease (PD)

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07348705 ↗ — RECRUITING; checked 2026-10-11

Study type: Interventional
Interventions: Clinician-based DBS programming; Maximum Beta power-based DBS programming; Broad-band electrophysiology-based DBS programming
Phases: NA
Sponsor: University of Florida
Start date reported by registry: 2026-01-15 (actual)

Registry updated: 2026-03-30 · Status last verified by the registry submitter: 2026-01

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Joshua Wong, MD · 352-294-5400 · Joshua.Wong@neurology.ufl.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Norman Fixel Institute for Neurological Diseases

Gainesville, Florida, United States

Recruiting

Hikaru Kamo, MD, PhD · Hikaru.Kamo@neurology.ufl.edu

Julia C Gonzalez, BA · Julia.Gonzalez@neurology.ufl.edu

Joshua Wong, MD

Hikaru Kamo, MD, PhD

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.