Recruiting · registry status

Using people’s own ratings to personalise brain stimulation

Researchers study how participants’ reports of their symptoms can help guide programming of implanted brain stimulators.

Learning by observing or collecting information · Study reference: NCT07336199

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date): 2024-12-02
Main measurements finished (planned): 2026-07-01
Study finished (planned): 2026-10-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

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Who can join?

Ages 35 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: Age between 35 and 80 years Clinically confirmed idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria Status post bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) Implanted DBS system suitable for electrophysiological recordings (prospective cohort: sensing-enabled IPG) Ability to understand study procedures and communicate reliably with the investigator Written informed consent provided Exclusion Criteria: Any condition impairing the ability to provide informed consent or comply with study procedures Presence of exclusion criteria for Parkinson's disease according to MDS criteria Manifest dementia according to ICD-10 criteria Severe neurological, psychiatric, or medical conditions interfering with study participation or assessments

Full study name & original research details

Official study title

Pairing Subjective Patient Rating and Local Field Potentials for DBS Programming

Short title used by the registry

Pairing Subjective Patient Rating and DBS Programming

Original description

This multicenter, prospective and retrospective diagnostic study investigates personalized programming strategies for deep brain stimulation (DBS) in patients with Parkinson's disease. DBS of the subthalamic nucleus (STN) is an established therapy for advanced Parkinson's disease; however, optimization of stimulation parameters remains time-consuming and resource-intensive due to the growing complexity of electrode designs and programming options. The PERCEPT-DBS study aims to improve DBS programming by combining subjective patient-reported outcomes with objective electrophysiological biomarkers. Specifically, the study examines the relationship between patients' subjective assessment of stimulation efficacy, measured using a visual analogue scale (VAS), and local field potentials (LFPs), with a focus on beta-band activity recorded from implanted DBS electrodes. These data are integrated with structural and functional neuroimaging to identify individualized stimulation "sweet spots" within the STN. A total of 24 patients with idiopathic Parkinson's disease treated with bilateral STN-DBS will be recruited across several German DBS centers. Participants undergo standardized clinical assessments, VAS-based blinded monopolar reviews, and LFP recordings using sensing-enabled implantable pulse generators. In addition, imaging-based analyses are performed to relate electrophysiological and subjective measures to anatomical and connectomic features. The primary objective is to determine whether electrophysiological markers correlate with subjective patient ratings and whether their overlap defines personalized optimal stimulation targets. By integrating patient perception with neurophysiological and imaging data, this study seeks to advance individualized DBS programming strategies and contribute to the development of more efficient, patient-centered, and potentially adaptive DBS therapies.

Conditions reported: Parkinson's Disease (PD)

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07336199 ↗ — RECRUITING; checked 2026-10-13

Study type: Observational
Interventions: No intervention (observational study)
Phases: Not reported
Sponsor: Ludwig-Maximilians - University of Munich
Start date reported by registry: 2024-12-02 (actual)

Registry updated: 2026-01-14 · Status last verified by the registry submitter: 2026-01

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Thomas Köglsperger, PD Dr. med., MHBA · +4989440073901 · thomas.koeglsperger@med.uni-muenchen.de

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

LMU University Hospital

München, Germany

Recruiting

PD Dr. med. Thomas Köglsperger, MHBA · 089440046433 · thomas.koeglsperger@med.uni-muenchen.de

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.