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Testing atomoxetine for freezing while walking

Researchers study whether the medicine atomoxetine reduces episodes when people with Parkinson’s become unable to continue walking.

Testing a treatment or activity · Study reference: NCT07316296

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date)
2026-01-01
Main measurements finished (planned)
2027-07-01
Study finished (planned)
2027-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 18 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Aged 18 years or older; * Diagnosis of idiopathic PD according to MDS Diagnostic Criteria; * Stabilised on optimal dopaminergic PD treatment for a minimum of four weeks prior to the baseline visit (Visit 1) and for the duration of the trial; * Presence of FOG symptoms on a daily basis; * Ability to walk for 10-meters unaided in the dopaminergic ON-state; * Ability to provide written informed consent in accordance with ICH-GCP and local regulations; * Willing and able to undergo all clinical trial assessments. Exclusion Criteria: * Current and/or previous (within 3 months) participation in a clinical trial; * Any contra-indications for undergoing MRI-scanning (e.g. claustrophobia or metal parts within the body such as DBS, an infusion pump or a pacemaker); * Co-morbidity that significantly impacts ambulation (e.g. orthopaedic or rheumatological ailments); * Severe cognitive impairment hampering the ability to comply with the study protocol; * Active psychosis that would impact the ability to comply with the study protocol; * Severe cardiovascular disorders: severe hypertension (Sustained (Sitting) hypertension of ≥180 mmHg systolic or ≥110 mmHg diastolic, defined by the average of three observations, each at least 3 minutes apart, with the participant having assumed the required position for at least 3 minutes), heart failure, arterial occlusive disease, angina, haemodynamically significant congenital heart disease, cardiomyopathies, myocardial infarction, potentially life-threatening arrhythmias, long QT interval syndrome (QTc \> 500ms Bazett-formula) and channelopathies that in the opinion of the study PI would significantly compromise participant safety; * Severe cerebrovascular disorders: cerebral aneurysm or recent/significant stroke; * Hepatic or renal insufficiency that in the opinion of the Principal Investigator would impact on the ability of the participant to safely participate; * Narrow angle glaucoma; * (History of) pheochromocytoma; * Use of noradrenergic agents; * Use of CYP2D6 inhibitors (SSRIs, quinidine, terbinafine); * Use of high dose salbutamol (or other beta2 agonists) that in the opinion of the Principal Investigator would impact on the ability of the participant to safely participate; * Pregnancy and/or breastfeeding; * Known hypersensitivity to atomoxetine.
Full study name & original research details

Official study title

Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach

Original description

The goal of this clinical trial is to learn if the medication atomoxetine can reduce freezing of gait in people with Parkinson's disease. The main questions it aims to answer is: Does atomoxetine reduce the frequency or severity of freezing of gait? What role does noradrenaline play in freezing of gait? Researchers will compare atomoxetine to a placebo to see if atomoxetine can improve freezing of gait in people with Parkinson's disease. Participants will: Visit the study site for measurements Take atomoxetine or placebo Perform walking assessments and undergo MRI Complete questionnaires about anxiety, stress, and quality of life

Conditions reported: Parkinson's Disease (PD); Freezing of Gait; Freezing of Gait Symptoms in Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Atomoxetine; Placebo
Phases
PHASE3
Sponsor
Radboud University Medical Center
Start date reported by registry
2026-01-01 (actual)

Registry updated: 2026-02-27 · Status last verified by the registry submitter: 2025-12

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

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Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Radboudumc

Nijmegen, Gelderland, Netherlands

Recruiting

Franka Goossens · +31243668426 · franka.goossens@radboudumc.nl

Facility not reported

Netherlands

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.