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Completed · registry status

Kynurenine Pathway in Parkinson's Disease

A plain-language introduction is being prepared for this study. Open it to read the original description, who can join and how to contact the team.

Testing a treatment or activity · Study reference: NCT07272564

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This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Completed; watching for results

Start (reported actual date)
2022-05-15
Main measurements finished (reported actual date)
2023-01-10
Study finished (reported actual date)
2023-06-18

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — completed

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

Periodontal inflammation and tryptophan-kynurenine metabolism in Parkinson’s disease
This paper mentions the study ID; the relationship needs review · 2026

Yilmaz M, Bakici A, Parlat R, Akpinar IN, Karaaslan R, Balci N, Toygar H, Kurgan S, Serdar MA, Kantarci A. Periodontal inflammation and tryptophan-kynurenine metabolism in Parkinson's disease. Clin Oral Investig. 2026 Mar 25;30(4):144. doi: 10.1007/s00784-026-06853-4. ↗
Registry derived research reference

Participation rules recorded for this study

Ages 18 years to 75 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * systemically healthy * clinical diagnosis of periodontitis * clinical diagnosis of periodontal health Exclusion Criteria: * history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months) * nonsurgical periodontal treatment (previous 6 months) * surgical periodontal treatment (previous 12 months) * presence of\<10 teeth * current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy) * diabetes * diagnosis of rheumatoid arthritis * pregnancy * lactating * smoking * excessive alcohol consumption.
Full study name & original research details

Official study title

Periodontal Inflammation and Tryptophan-Kynurenine Metabolism in Parkinson's Disease

Short title used by the registry

Kynurenine Pathway in Parkinson's Disease

Original description

Parkinson's disease is a slowly progressing disease that affects the motor and non-motor functions of an individual. Periodontitis is an inflammatory chronic disease resulting in the destruction of tooth supporting structures. Inflammation has been identified as an important factor in both diseases. Given this common mechanism, the question arises as to how they may affect each other when both diseases occur together. In this study, we compared the metabolism of tryptophan, a natural amino acid of the human body, and observed whether such a process provides a biological link between periodontitis and Parkinson's disease. We extracted the saliva and blood samples of patients of Parkinson's disease and periodontitis, patients of periodontitis and healthy human beings. Comparisons between the three were made, and it was found that levels of some metabolites of tryptophan were higher in the patients of both diseases. These findings raise the possibility of a close biological connection between periodontal and brain health. Through an increased understanding of this connection in the future, new approaches for diagnosis and treatment of Parkinson's disease and periodontitis may be developed.

Further description from the registry

Saliva and serum samples were collected from 20 Stage III, Grade B periodontitis patients with PAD (Parkinson+periodontitis group) and without PAD (periodontitis group), and 20 periodontally and systemically healthy (control group). Samples were analyzed for TRP, KYN, KYN/TRP ratio, KYNA, 3OHKYN, picolinic acid (PA), and quinolinic acid (QA) by liquid chromatography-mass spectrometry. Clinical periodontal parameters \[plaque index (PI), probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP)\] were recorded.

Conditions reported: Periodontal Diseases; Inflammation

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Saliva and serum sampling; Saliva, serum and GCF sampling
Phases
NA
Sponsor
Medipol University
Start date reported by registry
2022-05-15 (actual)

Registry updated: 2025-12-09 · Status last verified by the registry submitter: 2025-11

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

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Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Istanbul Medipol University, School of Dentistry

Istanbul, Fatih, Turkey (Türkiye)

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.