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tACS Modulates Speech and Cognitive Impairments in People With PD by Targeting the Medial Frontal Cortex

A plain-language introduction is being prepared for this study. Open it to read the original description, who can join and how to contact the team.

Testing a treatment or activity · Study reference: NCT07240272

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Completed; watching for results

Start (reported actual date)
2023-08-01
Main measurements finished (reported actual date)
2025-05-01
Study finished (reported actual date)
2025-08-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — completed

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

Theta tACS Over the Medial Frontal Cortex Modulates Executive Function in Parkinson's Disease: A Randomized, Sham-Controlled Study.
Listed by the registry as research derived from the study · 2026

Participation rules recorded for this study

Ages 35 years to 80 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1. Clinical diagnosis of Parkinson's disease. 2. Aged 35-80 years. 3. Absence of non-PD neurological disorders. 4. No hearing impairment, dementia, psychiatric abnormalities, or history of neurosurgical treatment. Exclusion Criteria: 1. Pregnancy. 2. Any contraindications to electrical stimulation.
Full study name & original research details

Official study title

Modulation of Executive Functions and Speech in Parkinson's Disease by Theta tACS Targeted at the Medial Frontal Cortex

Short title used by the registry

tACS Modulates Speech and Cognitive Impairments in People With PD by Targeting the Medial Frontal Cortex

Original description

This clinical trial aims to study whether transcranial alternating current stimulation (tACS) applied to the medial frontal cortex (MFC) can improve speech and cognitive function in people with Parkinson's disease (PD), and to evaluate the safety of tACS. The main goals are to answer the following questions: 1. Can tACS stimulation of the MFC improve executive functions in people with PD (such as reasoning, planning, inhibition, and complex problem-solving)? 2. Can it improve the integration of auditory information and speech motor control during communication? Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better speech and cognitive outcomes in PD patients. Participants will: 1. Receive one extra 20-minute session of either real or sham tACS each day for two weeks 2. Attend clinic visits before stimulation, right after the 2-week period, and again at 1 month and 3 months for assessments and tests 3. Have their executive function scores, speech performance, and related brain activity recorded

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
6Hz-tACS; Sham-tACS
Phases
NA
Sponsor
Ke Dong, MD
Start date reported by registry
2023-08-01 (actual)

Registry updated: 2025-11-20 · Status last verified by the registry submitter: 2025-09

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

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Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Status not reported

Facility not reported

China

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.