Recruiting · registry statusScanning the brain’s reward system in Parkinson’s and a sleep disorder
Researchers study brain systems involved in reward in people with Parkinson’s who also have a dream-sleep movement disorder.
Testing a treatment or activity · Study reference: NCT07213219
Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓
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Looking for volunteers
- Start (reported actual date)
- 2026-05-07
- Main measurements finished (planned)
- 2028-01-01
- Study finished (planned)
- 2029-01-01
Planned dates can move. A study finishing does not tell us when a paper will be published.
No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.
Changes we have recorded
These are dates we observed a change, not necessarily the dates it happened.
Papers connected to this study
No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.
Who can join?
Ages 45 years to 80 years · Does not accept healthy volunteers
These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.
Read all the rules for taking part
Sex eligibility reported by registry: all
Inclusion Criteria:
* Patients aged 45 to 80 years
* Patients diagnosed with idiopathic Parkinson's disease (PD) according to the Movement Disorder Society criteria
* Duration of Parkinson's disease progression ≥ 3 years
* Patients receiving chronic dopaminergic treatment including levodopa for at least one year to avoid tolerance issues during acute levodopa administration
* Ability to cooperate and understand, allowing strict compliance with the conditions set forth in the protocol
* Patients affiliated with or beneficiaries of a social security system
* Volunteer patients capable of providing informed consent to participate in the research
Exclusion Criteria:
* Patients suffering from neurological disorders other than idiopathic Parkinson's disease (PD)
* Patients with severe depression (Beck Depression Inventory \\\[20\] (BDI) score \> 30), apathy (Starkstein scale \\\[21\] score ≥ 14), cognitive impairment (Montreal Cognitive Assessment \\\[MoCA\] \\\[22\] score \< 25).
* Patients with impulse control disorders, defined by either of the following:
* A score of ≥ 6 on the "Pathological Gambling" item, ≥ 8 on the "Compulsive Buying" item, ≥ 8 on the "Sexual Behavior" item, or ≥ 7 on the "Eating Behavior" item, and more than one positive response (score \> 0) on the corresponding QUIP-RS items for Gambling, Compulsive Buying, Sexual Behavior, and Eating Behavior.
* A total QUIP-RS score ≥ 10.
* Patients with severe motor symptoms: patients with an MDS-UPDRS III score \> 45 will be excluded to avoid severe discomfort or interfering tremor (tremor item ≥ 3 in any body part) in the OFF state during PET-MRI acquisition. Patients with severe dyskinesias will also be excluded due to technical issues related to movement
* Patients under guardianship, curatorship, deprived of liberty, or under legal protection
* Pregnant or breastfeeding women
* Patients with contraindications to PET-MRI (e.g., those with pacemakers or insulin pumps, metallic prostheses or intracerebral clips, claustrophobia, neurosensorial stimulators or implantable defibrillators, cochlear implants, ferromagnetic ocular or cerebral foreign bodies near nervous structures, uncooperative or agitated patients, neurosurgical ventriculoperitoneal shunts, dental appliances)
* Refusal to participate
Full study name & original research details
Official study title
Exploration of the Reward System in Parkinson's Patients With Paradoxical Sleep Behavior Disorders: a Multimodal Imaging Study
Short title used by the registry
PET-MRI of Reward System in Parkinson's Disease With RBD
Original description
Impulse control disorders (ICDs) are frequently observed in Parkinson's disease (PD) and can have a major functional impact on the quality of life of both the patient and their entourage. The primary risk factor for the emergence of ICDs in PD is long-term dopaminergic treatment, but other risk factors, such as rapid eye movement sleep behavior disorder (RBD), have recently been identified. The mechanisms leading to ICDs in PD remain debated, but it has been shown that the dopaminergic mesocorticolimbic pathways play a key role in reward, learning, and reinforcement processes, as well as in the regulation of impulsivity. PET studies using \[11C\]raclopride, a tracer that allows evaluation of the postsynaptic availability of dopamine D2/D3 receptors, have demonstrated abnormal sensitization of the mesocorticolimbic dopaminergic system (the reward system), particularly in the ventral striatum, in Parkinson's patients with ICDs when presented with appetitive stimuli or during gambling tasks. However, this has never been studied in patients with and without RBD. Parkinson's patients with RBD may present greater impairment of mesocorticolimbic pathways than those without RBD, particularly abnormal sensitization and postsynaptic modifications of the dopaminergic system, which could predispose patients to the emergence of ICDs when exposed to dopaminergic agonists. Confirming a particular pattern of denervation in Parkinson's patients with RBD that may favor the emergence of ICDs constitutes a personalized medicine approach with a readily identifiable risk marker in routine clinical practice and offers the possibility of adapting the management of these patients.
The main objective of this study is to investigate the availability of D2 dopaminergic receptors in subcortical structures (particularly the mesocorticolimbic system) in patients with idiopathic Parkinson's disease, depending on the presence or absence of RBD
Conditions reported: Parkinson's Disease (PD)
Registry records for this study
Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.
- Study type
- Interventional
- Interventions
- PET-MRI (Positron Emission Tomography - Magnetic Resonance Imaging).
- Phases
- NA
- Sponsor
- University Hospital, Clermont-Ferrand
- Start date reported by registry
- 2026-05-07 (actual)
Registry updated: 2026-07-08 · Status last verified by the registry submitter: 2025-10
Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.
Contact the research team
Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.
Lise LACLAUTRE · +334.73.754.963 · promo_interne_drci@chu-clermontferrand.fr
Study locations
Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.
CHU Clermont-Ferrand, Clermont-Ferrand,
Clermont-Ferrand, France
RecruitingLise LACLAUTRE · +33473754963 · promo_interne_drci@chu-clermontferrand.fr
Charlotte BEAL
CH Le Puy en Velay
Le Puy-en-Velay, France
RecruitingJeremy DASSA
CHRU Lyon
Lyon, France
RecruitingStéphane THOBOIS
Facility not reported
France
Status not reportedThe original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.