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Testing focused ultrasound for movement and thinking

Researchers compare an ultrasound brain stimulation system with an inactive version, checking safety and early signs of effects in Parkinson’s.

Testing a treatment or activity · Study reference: NCT07207122

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

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Looking for volunteers

Start (reported actual date)
2025-10-08
Main measurements finished (planned)
2026-12
Study finished (planned)
2026-12

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 22 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Adults aged 22 to 80 years. * Diagnosis of idiopathic Parkinson's disease. * MDS-UPDRS Part III score ≥25 in OFF-medication state at baseline. * Stable dopaminergic therapy for at least 30 days prior to enrollment. * English proficiency. * Normal or corrective hearing and vision. * Ability to provide informed consent (or availability of an LAR) and comply with protocol requirements. Exclusion Criteria: * Atypical or secondary Parkinsonism. * Prior deep brain stimulation or intracranial surgery. * MoCA score \<23. * Severe psychiatric illness (e.g., psychosis, suicidality, untreated major depression). * History of seizure or intracranial pathology. * Significant neurologic disease (e.g. brain tumor, multiple sclerosis) * Contraindication to MRI or ultrasound. * Unstable systemic medical conditions. * Active malignancy or history of cancer within the past 5 years. * Pregnancy or breastfeeding. * Participation in another interventional trial.
Full study name & original research details

Official study title

Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease

Original description

This is a pilot randomized, sham-controlled, double-blind, multi-center study evaluating the safety and preliminary effectiveness of the Gen0Bh Transcranial Focused Ultrasound System for the treatment of motor symptoms in individuals with idiopathic Parkinson's disease.

Further description from the registry

Participants will be randomized in a 1:1 allocation to receive either active or sham stimulation. Both participants and outcome assessors will remain blinded to treatment assignment. The study consists of 20 treatment sessions administered over approximately 4-6 weeks, followed by longitudinal follow-up through 3 months.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Gen0Bh Transcranial Focused Ultrasound System (Active); Gen0Bh Transcranial Focused Ultrasound System (Sham)
Phases
NA
Sponsor
Sanmai Technologies PBC dba Sanmai
Start date reported by registry
2025-10-08 (actual)

Registry updated: 2026-07-31 · Status last verified by the registry submitter: 2026-07

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Clinical Team · 408-455-3817 · clinical@sanm.ai

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

University of Arizona

Tucson, Arizona, United States

Recruiting

Erica Lord · (520) 866-1033 · ericacook@arizona.edu

Alexa Rukstela · (520) 866-1033 · alexarukstela@arizona.edu

John Allen, Ph.D.

The Regenesis Project

Santa Monica, California, United States

Recruiting

Sheena Tan · 310-829-5968 · stan@theneuroassociates.com

Kevin Enemuo · (310) 829-5968 · kenemuo@theneuroassociates.com

Sheldon E Jordan, MD, FAAN

UF - McKnight Brain Institute

Gainesville, Florida, United States

Recruiting

Damon Carpenter · 352-294-5837 · carpenter.nb@phhp.ufl.edu

Andrew O'Shea · (352) 294-8631 · aoshea@phhp.ufl.edu

Joseph Gullett, Ph.D.

Radial Midtown Manhattan

New York, New York, United States

Recruiting

Angelique Lucien · (516) 908-8540 · ask@meetradial.com

Ahmed Tahseen, M.D · (516) 908-8540 · ask@meetradial.com

Owen Muir, M.D

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.