RESEARCH / PARTICIPATIONBack to the library
← Find a study
Recruiting · registry status

Testing prasinezumab in early Parkinson’s

Researchers are checking the effects and safety of the study medicine prasinezumab, given through a vein, compared with an inactive treatment.

Testing a treatment or activity · Study reference: NCT07174310

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

Open the official registry record ↗

Who can join?

Ages 50 years to 85 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Body weight within 40-110 kilograms (kg) (88-242 pounds \[lbs\]) and a body mass index within the range 18-34 kg/m2 * Diagnosis of idiopathic PD based on Movement Disorder Society (MDS) criteria * Has received monotherapy treatment * An MDS-UPDRS Part IV score of 0 at screening and prior to randomization * Hoehn and Yahr (H\&Y) Stage 1 or 2 off medication at screening and prior to randomization * Agreement to adhere to the contraception requirements Exclusion Criteria: * Pregnant or breastfeeding, or intention of becoming pregnant during the study or within the time frame in which contraception is required * Medical history indicating a parkinsonian syndrome other than idiopathic PD * Diagnosis of a significant neurologic disease other than PD * Chronic uncontrolled hypertension
Full study name & original research details

Official study title

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early-Stage Parkinson's Disease

Short title used by the registry

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

Original description

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with levodopa.

Conditions reported: Parkinson's Disease

Study type
Interventional
Interventions
Prasinezumab; Placebo
Phases
PHASE3
Sponsor
Hoffmann-La Roche
Start date reported by registry
2025-11-24 (actual)

Registry updated: 2026-10-06 · Status last verified by the registry submitter: 2026-10

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Reference Study ID Number: BN44715 https://forpatients.roche.com/ No attachments to email below. · 888-662-6728 (U.S. and Canada) · global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

University of Alabama at Birmingham

Birmingham, Alabama, United States

Recruiting

Barrow Neurological Institute

Phoenix, Arizona, United States

Recruiting

Neurology Center of North Orange County

Fullerton, California, United States

Recruiting

UC San Diego

La Jolla, California, United States

Recruiting

Keck School of Medicine of USC

Los Angeles, California, United States

Recruiting

UCLA Neurology Outpatient Clinic

Los Angeles, California, United States

Recruiting

Parkinson?s Research Centers of America ? Palo Alto

Palo Alto, California, United States

Recruiting

Profound Research LLC at The Neurology Center of Southern California

Pasadena, California, United States

Recruiting

UCSF Weill Institute for Neurosciences

San Francisco, California, United States

Recruiting

Stanford Neuroscience Health Center (SNHC)

Stanford, California, United States

Recruiting

Rocky Mountain Movement Disorders

Englewood, Colorado, United States

Recruiting

Institute for Neurodegenerative Disorders

New Haven, Connecticut, United States

Recruiting

Georgetown University

Washington D.C., District of Columbia, United States

Recruiting

JEM Research LLC

Atlantis, Florida, United States

Recruiting

Parkinson's Disease and Movement Disorders Center of Boca Raton

Boca Raton, Florida, United States

Recruiting

K2 - Villages

Lady Lake, Florida, United States

Recruiting

K2 Medical Research-Maitland

Maitland, Florida, United States

Recruiting

Baptist Hospital of Miami

Miami, Florida, United States

Recruiting

Charter Research - Winter Park/Orlando

Orlando, Florida, United States

Recruiting

Advent Health Orlando

Orlando, Florida, United States

Recruiting

USF Parkinsons Disease and Movement Disorders Center

Tampa, Florida, United States

Recruiting

Grady Memorial Hospital

Atlanta, Georgia, United States

Recruiting

Hawaii Pacific Neuroscience

Honolulu, Hawaii, United States

Recruiting

Northwestern University Feinberg School Of Medicine

Chicago, Illinois, United States

Recruiting

University of Kansas Medical Center

Kansas City, Kansas, United States

Recruiting

Massachusetts General Hospital

Boston, Massachusetts, United States

Recruiting

Quest Research Institute

Farmington Hills, Michigan, United States

Recruiting

Washington Uni School of Medicine

St Louis, Missouri, United States

Recruiting

Cleveland Clinic Lou Ruvo

Las Vegas, Nevada, United States

Recruiting

Renown Health

Reno, Nevada, United States

Recruiting

Hackensack University Medical Center;Department of Neurology, Neuroscience Institute

Paramus, New Jersey, United States

Recruiting

University of New Mexico

Albuquerque, New Mexico, United States

Recruiting

Dent Neurological Institute

Amherst, New York, United States

Recruiting

Parkinson's Research Centers of America - Long Island

Commack, New York, United States

Recruiting

Weill Cornell Medical College

New York, New York, United States

Recruiting

Columbia University Medical Center

New York, New York, United States

Recruiting

Asheville Neurology

Asheville, North Carolina, United States

Recruiting

Duke University Medical Center

Durham, North Carolina, United States

Recruiting

NeuroCare Center

Canton, Ohio, United States

Recruiting

Cleveland Clinic

Cleveland, Ohio, United States

Recruiting

The Movement Disorder Clinic of Oklahoma

Tulsa, Oklahoma, United States

Recruiting

Oregon Health and Science University

Portland, Oregon, United States

Recruiting

University Pennsylvania Hospital

Philadelphia, Pennsylvania, United States

Recruiting

Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

Recruiting

Avera Medical Group

Sioux Falls, South Dakota, United States

Recruiting

Veracity Neuroscience

Memphis, Tennessee, United States

Recruiting

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Recruiting

Texas Neurology PA

Dallas, Texas, United States

Recruiting

Central Texas Neurology Consultants

Round Rock, Texas, United States

Recruiting

University of Vermont Medical Center

Burlington, Vermont, United States

Recruiting

University of Virginia Health System

Charlottesville, Virginia, United States

Recruiting

VCU Health North Hospital

Richmond, Virginia, United States

Recruiting

West Virginia University

Morgantown, West Virginia, United States

Recruiting

Southern Neurology

Kogarah, New South Wales, Australia

Recruiting

Westmead Hospital

Westmead, New South Wales, Australia

Recruiting

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

Recruiting

Monash Health

Clayton, Victoria, Australia

Recruiting

Royal Melbourne Hospital

Parkville, Victoria, Australia

Recruiting

The Alfred Hospital

Prahan, Victoria, Australia

Recruiting

Perron Institute for Neurological and Translational Science

Nedlands, Western Australia, Australia

Recruiting

Medizinische Universität Graz

Graz, Austria

Recruiting

Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck

Innsbruck, Austria

Recruiting

Kepler Universitätsklinikum GmbH - Neuromed Campus

Linz, Austria

Recruiting

Medizinische Universität Wien

Vienna, Austria

Withdrawn

Klinik Ottakring

Vienna, Austria

Recruiting

Santa Casa de Misericordia de Salvador

Salvador, Estado de Bahia, Brazil

Recruiting

L2 Ip Instituto de Pesquisas Clinicas Ltda ME

Brasília, Federal District, Brazil

Recruiting

Hospital das Clinicas - UFMG

Belo Horizonte, Minas Gerais, Brazil

Recruiting

Instituto de Neurologia de Curitiba

Curitiba, Paraná, Brazil

Recruiting

Núcleo de Pesquisa do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, Brazil

Recruiting

Faculdade de Medicina de Ribeirão Preto - Universidade de Sao Paulo

Ribeirão Preto, São Paulo, Brazil

Recruiting

Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP*X*

São José do Rio Preto, São Paulo, Brazil

Recruiting

Centro de Pesquisas Clinicas

São Paulo, São Paulo, Brazil

Recruiting

University Health Network

Toronto, Ontario, Canada

Recruiting

CHUM

Montreal, Quebec, Canada

Recruiting

Montreal Neurological Institute and Hospital

Montreal, Quebec, Canada

Recruiting

Beijing Friendship Hospital Affiliated of Capital University of Medical Science

Beijing, China

Recruiting

Xuanwu Hospital, Capital Medical University

Beijing, China

Recruiting

Beijing Tian Tan Hospital,Capital Medical University

Beijing, China

Recruiting

Beijing Hospital of Ministry of Health

Beijing, China

Recruiting

The First Hospital of Jilin University

Changchun, China

Recruiting

West China Hospital of Sichuan University

Chengdu, China

Recruiting

The First Affiliated Hospital, Chongqing Medical University

Chongqing, China

Recruiting

Fujian Medical University Union Hospital

Fuzhou, China

Recruiting

The First Affiliated Hospital of Sun Yat-sen University

Guangzhou, China

Recruiting

Guangdong Provincial People's Hospital

Guangzhou, China

Recruiting

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, China

Recruiting

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, China

Recruiting

Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

Hangzhou, China

Recruiting

Nanjing Brain Hospital

Nanjing, China

Recruiting

Ruijin Hospital Shanghai Jiaotong University School of Medicine

Shanghai, China

Recruiting

Huashan Hospital, Fudan University

Shanghai, China

Recruiting

Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, China

Recruiting

The Second Affiliated Hospital of Soochow University

Suzhou, China

Recruiting

Tianjin Medical University General Hospital

Tianjin, China

Recruiting

First Affiliated Hospital of Medical College of Xi'an Jiaotong University

Xi'an, China

Recruiting

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, China

Recruiting

Aarhus Universitetshospital Skejby

Aarhus N, Denmark

Recruiting

Regionshospitalet Gødstrup;Neurologisk Afdeling

Herning, Denmark

Recruiting

Bispebjerg Hospital;Neurologisk Afdeling

København NV, Denmark

Recruiting

AP-HM- Hôpital de La Timone

Marseille, Bouches-du-Rhône, France

Recruiting

Hospices Civils de Lyon - Hôpital Pierre Wertheimer

Bron, Rhône, France

Recruiting

CHU de Clermont-Ferrand - Site Gabriel-Montpied

Clermont-Ferrand, France

Recruiting

APHP - Hopital Henri Mondor

Créteil, France

Recruiting

CHU de Grenoble - Hôpital André Michallon

La Tronche, France

Recruiting

Hopital Roger Salengro

Lille, France

Recruiting

CHU de Limoges - Hôpital Dupuytren

Limoges, France

Recruiting

CHU de Montpellier - Hôpital Gui de Chauliac

Montpellier, France

Recruiting

CHU de Nice Hopital Pasteur

Nice, France

Recruiting

APHP - Hopital de la Pitie Salpetriere

Paris, France

Recruiting

CHU de Toulouse - Hôpital Purpan

Toulouse, France

Recruiting

Kliniken Beelitz GmbH

Beelitz, Germany

Recruiting

Charite Universitätsmed. Berlin

Berlin, Germany

Recruiting

Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin

Berlin, Germany

Recruiting

St. Josef-Hospital, Klinik für Neurologie

Bochum, Germany

Recruiting

Universitätsklinikum "Carl Gustav Carus"

Dresden, Germany

Recruiting

Heinrich-Heine Universitätsklinik Düsseldorf

Düsseldorf, Germany

Recruiting

Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie

Erlangen, Germany

Recruiting

Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

Freiburg im Breisgau, Germany

Recruiting

Medizinische Hochschule Hannover, Klinik für Neurologie

Hanover, Germany

Recruiting

Universitätsklinikum Heidelberg, Neurologische Klinik, Abteilung für Neuroradiologie

Heidelberg, Germany

Recruiting

Universität Des Saarlandes

Homburg, Germany

Recruiting

Paracelsus Elena Klinik Kassel

Kassel, Germany

Recruiting

Klinikum rechts der Isar der TU München

Munich, Germany

Recruiting

LMU Klinikum, Neurologische Klinik und Poliklinik

München, Germany

Recruiting

Universitatsklinikum Munster

Münster, Germany

Recruiting

Universitaettsklinikum Tübingen

Tübingen, Germany

Recruiting

Universitätsklinikum Würzburg, Neurologische Klinik und Poliklinik

Würzburg, Germany

Recruiting

Università degli studi della Campania Luigi Vanvitelli

Naples, Campania, Italy

Recruiting

Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona

Salerno, Campania, Italy

Recruiting

Ospedale Bellaria

Bologna, Emilia-Romagna, Italy

Recruiting

San Raffaele Cassino

Cassino, Lazio, Italy

Recruiting

IRCCS San Raffaele;Clinical Trial Center

Rome, Lazio, Italy

Recruiting

Policlinico Universitario Agostino Gemelli

Rome, Lazio, Italy

Recruiting

Irccs A.O.U.San Martino Ist

Genoa, Liguria, Italy

Recruiting

Azienda Ospedaliera Spedali Civili

Brescia, Lombardy, Italy

Recruiting

Centro Parkinson e Parkinsonismi

Milan, Lombardy, Italy

Recruiting

IRCCS Ospedale San Raffaele

Milan, Lombardy, Italy

Recruiting

IRCCS Istituto Neurologico Carlo Besta

Milan, Lombardy, Italy

Recruiting

A.O. Universitaria Pisana

Pisa, Tuscany, Italy

Recruiting

Azienda Ospedaliera di Padova

Padova, Veneto, Italy

Recruiting

Instituto Nacional de Neurologia y Neurocirugia

Mexico City, Mexico CITY (federal District), Mexico

Recruiting

Hospital General de Mexico

Mexico City, Mexico CITY (federal District), Mexico

Recruiting

Podlaskie Centrum Psychogeriatrii

Bia?ystok, Poland

Withdrawn

NZOZ Vitamed

Bydgoszcz, Poland

Recruiting

Szpital Sw. Wojciecha

Gda?sk, Poland

Recruiting

NEURO-CARE Sp. z o.o. Sp. Komandytowa

Katowice, Poland

Recruiting

Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K

Krakow, Poland

Recruiting

Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.

Lublin, Poland

Recruiting

Instytut Zdrowia Dr Boczarska-Jedynak Sp. z o.o. Sp. k.

Oświęcim, Poland

Recruiting

Nmedis sp. z o.o.

Rzeszów, Poland

Recruiting

NeuroProtect

Warsaw, Poland

Recruiting

Mazowiecki Szpital Bródnowski w Warszawie Sp. z o.o.

Warsaw, Poland

Recruiting

Hospital de Braga

Braga, Portugal

Recruiting

Hospital da Luz Coimbra

Coimbra, Portugal

Recruiting

Hospital Dr. Nélio Mendonça;Serviço de Neurologia

Funchal, Portugal

Recruiting

Hospital da Senhora da Oliveira-Guimarães

Guimarães, Portugal

Recruiting

Hospital de Santa Maria

Lisbon, Portugal

Recruiting

Hospital Pedro Hispano

Matosinhos Municipality, Portugal

Recruiting

CNS - Campus Neurológico

Torres Vedras, Portugal

Recruiting

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Recruiting

Asan Medical Center

Seoul, South Korea

Recruiting

Samsung Medical Center

Seoul, South Korea

Recruiting

Boramae Medical Center

Seoul, South Korea

Recruiting

Korea University Guro Hospital

Seoul, South Korea

Recruiting

Seoul National University Hospital

Seoul, South Korea

Recruiting

Hospital General Universitario de Elche

Elche, Alicante, Spain

Recruiting

Hospital General De Catalunya

Sant Cugat del Vallès, Barcelona, Spain

Recruiting

Policlinica Guipuzcoa

Donostia / San Sebastian, Guipuzcoa, Spain

Recruiting

Complejo Hospitalario Universitario A Coruña

A Coruña, LA Coruna, Spain

Recruiting

Hospital Universitario Fundación Alcorcón

Alcorcón, Madrid, Spain

Recruiting

Hospital Quiron de Madrid

Pozuelo de Alarcón, Madrid, Spain

Recruiting

Hospital Universitari Vall d Hebron

Barcelona, Spain

Recruiting

Hospital Clinic Barcelona

Barcelona, Spain

Recruiting

Hospital Ruber Juan Bravo

Madrid, Spain

Recruiting

Hospital Universitario de La Princesa

Madrid, Spain

Recruiting

Hospital Univ 12 de Octubre

Madrid, Spain

Recruiting

Hospital Regional Universitario de Malaga ? Hospital General

Málaga, Spain

Recruiting

Hospital Universitario Virgen del Rocio

Seville, Spain

Recruiting

Changhua Christian Hospital

Changhua County, Taiwan

Recruiting

China Medical University Hospital

North Dist., Taiwan

Recruiting

National Cheng Kung University Hospital

Tainan, Taiwan

Recruiting

National Taiwan University Hospital

Taipei, Taiwan

Recruiting

Taipei Veterans General Hospital

Taipei, Taiwan

Recruiting

Chang Gung Memorial Hospital - Linkou

Taoyuan City, Taiwan

Recruiting

Ninewells Hospital, Dundee- Scotland

Dundee, United Kingdom

Recruiting

Royal Devon and Exeter Hospital (Wonford)

Exeter, United Kingdom

Recruiting

Royal London Hospital

London, United Kingdom

Recruiting

Charing Cross Hospital

London, United Kingdom

Recruiting

Campus for Ageing and Vitality

Newcastle, United Kingdom

Recruiting

Oxford University Hospitals NHS Foundation Trust

Oxford, United Kingdom

Recruiting

Plymouth Hospitals NHS Trust - Derriford Hospital

Plymouth,Devon, United Kingdom

Recruiting

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.