Recruiting · registry statusTesting gentle electrical brain stimulation for swallowing
Researchers test whether electrical stimulation applied through the scalp affects swallowing difficulties in people with Parkinson’s.
Testing a treatment or activity · Study reference: NCT07153692
Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓
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Results reported
- Start (reported actual date)
- 2025-07-17
- Main measurements finished (planned)
- 2029-12-31
- Study finished (planned)
- 2030-03-31
Planned dates can move. A study finishing does not tell us when a paper will be published.
No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.
Changes we have recorded
These are dates we observed a change, not necessarily the dates it happened.
Papers connected to this study
Ding X, Gao J, Xie C, Xiong B, Wu S, Cen Z, Lou Y, Lou D, Xie F, Luo W. Prevalence and clinical correlation of dysphagia in Parkinson disease: a study on Chinese patients. Eur J Clin Nutr. 2018 Jan;72(1):82-86. doi: 10.1038/ejcn.2017.100. Epub 2017 Jul 12. ↗
Registry results reference
Henry KA, Singh R, Zhang N, Lyons MK, McNett K, Neal MT, Mehta SH. Effect of STN/GPi DBS on swallowing function in Parkinson's disease as assessed by Video fluoroscopy: A retrospective study. Parkinsonism Relat Disord. 2022 Oct;103:136-140. doi: 10.1016/j.parkreldis.2022.08.017. Epub 2022 Sep 11. ↗
Registry results reference
Wang P, Wang B, Chen X, Xiong B, Xie F, Wu S, Tang Y, Chen S, Ding X, Liu P, Luo W. Six-Year Follow-Up of Dysphagia in Patients with Parkinson's Disease. Dysphagia. 2022 Oct;37(5):1271-1278. doi: 10.1007/s00455-021-10387-0. Epub 2021 Nov 26. ↗
Registry results reference
Gandhi P, Steele CM. Effectiveness of Interventions for Dysphagia in Parkinson Disease: A Systematic Review. Am J Speech Lang Pathol. 2022 Jan 18;31(1):463-485. doi: 10.1044/2021_AJSLP-21-00145. Epub 2021 Dec 10. ↗
Registry results reference
Dashtelei AA, Nitsche MA, Salehinejad MA, Habibi AH, Bakhtyiari J, Khatoonabadi AR. Adjunctive transcranial direct current stimulation to improve swallowing functions in Parkinson's disease. EXCLI J. 2024 Jan 18;23:95-107. doi: 10.17179/excli2023-6496. eCollection 2024. ↗
Registry results reference
Who can join?
Ages 18 years to 100 years · Does not accept healthy volunteers
These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.
Read all the rules for taking part
Sex eligibility reported by registry: all
Inclusion Criteria:
* Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy;
* VFSS examination indicates dysphagia;
* Mini-Mental State Examination (MMSE) score \>23;
* Willing to cooperate with the study and sign the informed consent form;
Exclusion Criteria:
* Comorbid with other diseases that cause dysphagia;
* Comorbid with pneumonia, or severe cardiac/renal insufficiency;
* Having metal implants in the body
* With cognitive impairment or inability to cooperate.
Full study name & original research details
Official study title
Clinical Efficacy and Mechanism of tDCS for Dysphagia in Patients With Parkinson's Disease
Short title used by the registry
Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD
Original description
This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment).
Assessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions/networks.
Correlations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.
Further description from the registry
This study aims to verify the efficacy of tDCS in treating dysphagia in PD and explore its mechanism. Subjects are randomly divided into two groups: the control group receives sham tDCS as well as the conventional dysphagia treatment, while the experimental group undergoes real tDCS combined with conventional dysphagia treatment.
All subjects will be evaluated before treatment, after treatment, and 3 months later (follow-up). Swallowing function in both groups will be assessed using the gold standard VFSS and swallowing scales. Additionally, techniques including amplitude of low frequency fluctuation (ALFF) and functional connectivity (FC) in rs-fMRI or fNIRS will be used to observe changes in abnormal brain regions and brain network connectivity before and after treatment in both groups.
This study will also explore the correlation between swallowing function recovery and the alteration of brain function, compare the imaging differences between the two groups, and thereby reveal the neurophysiological mechanism underlying tDCS in the treatment of PD-related dysphagia.
Conditions reported: Parkinson's Disease and Parkinsonism; Dysphagia
Registry records for this study
Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.
- Study type
- Interventional
- Interventions
- tDCS; Conventional Dysphagia Treatment; sham tDCS
- Phases
- NA
- Sponsor
- Wang Ping
- Start date reported by registry
- 2025-07-17 (actual)
Registry updated: 2025-09-04 · Status last verified by the registry submitter: 2025-08
Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.
Contact the research team
Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.
Ping Wang, MS · 15158113194 · wangping6288@zju.edu.cn
Bo Wang, MD · wangke1121@zju.edu.cn
Study locations
Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.
Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
RecruitingPing Wang, MS · 15158113194 · 441350830@qq.com
Bo Wang, MD · wangke1121@zju.edu.cn
The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.