Recruiting · registry status

Testing a daily nutritional supplement

Researchers study whether a tailored amino acid supplement, containing building blocks of protein, affects nutrition, body composition and physical function in Parkinson’s.

Testing a treatment or activity · Study reference: NCT07115563

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported actual date): 2025-10-31
Main measurements finished (planned): 2027-09
Study finished (planned): 2027-11

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 50 years to 90 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusionary Criteria: * Male and Females. * 50-80 Years. * Previous diagnosis of idiopathic Parkinson's Disease by patient report. * Use of dopamine replacement medication (e.g. levodopa) for at least 2 years. * On a stable dose of dopamine replacement medication for at least 3 months with no plans for change in the next two months. Exclusionary criteria * Apparent cognitive impairment as determined by phone screening (Telephone Interview for Cognitive Status \<29). * Diagnosis of Parkinsonism or atypical Parkinson's Disease. * Prescription of Dopamine antagonist. * Any unstable medical condition. * Use of Deep Brain Stimulation. * Gastric or Bowel resection surgery. * Contraindications to blood draw.

Full study name & original research details

Official study title

Effects of Targeted Amino Acid Supplementation for People With Parkinson's Disease on Amino Acid Profiles and Health Related Markers

Short title used by the registry

Daily Amino Acid Supplementation for People With Parkinson's Disease

Original description

The goal of this clinical trial is to learn if a tailored amino acid supplement works to help adults living with Parkinson's disease to improve nutrition, metabolic function, body composition, and physical and mental function. The main questions it aims to answer are: Does the tailored amino acid supplement increase essential amino acids (nutritional status)? Does the tailored amino acid supplement increase an antioxidant (complex amino acid) and decrease an amino acid associated with oxidative stress? Does the tailored amino acid supplement improve physical and mental health compared to a placebo supplement? Researchers will compare the tailored amino acid supplement to a placebo (a look-alike substance that contains no active ingredients) to see if the tailored amino acid supplements work to support health for people with Parkinson's disease. Participants will: Take the tailored amino acid supplement or a placebo every day for 6 months, visit the lab at baseline, after 3 months, and after 6 months for fasting blood draws, body composition assessment, and physical and mental health testing and keep a diary of their food intake and supplement intake.

Further description from the registry

The purpose of this trial is to determine the effects of a targeted amino acid supplement (T-AA) specifically designed to correct characteristic amino acid deficiencies and meet the unique nutritional needs of people with Parkinson's disease (PD) on 1) plasma amino acid (AA) bioavailability, 2) metabolic function, 3) body composition, 4) physical function and 5) self-reported outcomes.

Conditions reported: Parkinson Disease (PD)

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07115563 ↗ — RECRUITING; checked 2026-10-11
ClinicalTrials.gov · NCT07115563 ↗ — Recruiting; WHO ICTRP processed 2026-08-24; checked 2026-10-11

Study type: Interventional
Interventions: Targeted Amino Acid Supplement; Control (placebo)
Phases: NA
Sponsor: Cristina Colon-Semenza
Start date reported by registry: 2025-10-31 (actual)

Registry updated: 2026-08-13 · Status last verified by the registry submitter: 2026-08

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Carlos Rehbein, MS · 860-634-8203 · carlos.rehbein@uconn.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

UConn Health

Farmington, Connecticut, United States

Recruiting

Carlos Rehbein, MS · 860-486-1121 · carlos.rehbein@uconn.edu

Bernardo Rodrigues, MD, PhD

University of Connecticut

Storrs, Connecticut, United States

Recruiting

Jacob Earp, MS · 860-486-2671 · jacob.earp@uconn.edu

Carlos Rehbein · carlos.rehbein@uconn.edu

Jacob Earp, PhD

Cristina Colon-Semenza, PT, MPT, PhD

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.