Recruiting · registry status

Vitamin D and automatic control of the heart

Researchers study whether vitamin D3 affects automatic control of heart function in men with Parkinson’s and low vitamin D levels.

Testing a treatment or activity · Study reference: NCT07084597

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (planned): 2025-07
Main measurements finished (planned): 2025-10
Study finished (planned): 2025-10

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

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Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 51 years to 70 years · Does not accept healthy volunteers

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Read all the rules for taking part

Sex eligibility reported by registry: male

IInclusion criteria: * Male patients with of Parkinson's disease diagnosed by neurologist with unilateral or bilateral involvement and mild to moderate disability according to Hoehn and Yahr (H-Y) scale (I-III) * Age: 51-70 years * BMI: 18.5-24.9 kg/m2 * Vitamin D3 deficient or insufficient * On Levodopa medication Exclusion criteria: 1. Patients with a history of drug abuse including alcoholism. 2. Patients on following drugs will be excluded- * Antioxidant vitamin supplements * Lipid lowering medications * Antihypertensive drug * Anti-arrhythmic drug * Sedatives 3. All patients with the history of or clinical manifestation of currently suffering from following diseases \& condition will be excluded * Severe Cardiovascular disorders * Severe neurological disorders * Severe Respiratory disorders * Severe Renal insufficiency (S. Creatinine \> 1.5 mg/dl, Acute or chronic kidney disease) * Severe Endocrine disease * Severe Arthritis * Severe Liver diseases * Severe Neoplastic disease * Severe Psychiatric disorder * Current use of iron, zinc, calcium, magnesium and multivitamin supplementation * Already performing yoga or breathing exercise * Hypercalcemia

Full study name & original research details

Official study title

Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male

Short title used by the registry

Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Parkinson's Disease Patients With Hypovitaminosis D

Original description

The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male Parkinson's disease patients with hypovitaminosis D Main questions it aims to answer are: 1. Does vitamin D improves heart rate variability(HRV) in male Parkinson's disease patients ? 2. Does vitamin D improves cardiac autonomic nerve function in male Parkinson's disease patients ? It is a self control trial. Vitamin D3 deficient Parkinson's disease participants will a. undergo through baseline HRV test b. Then they will take vitamin D3 capsule 50000 IU once in a week for 8 consecutive weeks c. Then after intervention with vitamin D supplementation post interventional HRV will be done. Researcher will compare pre intervention(pre test) and post intervention(post test) value of HRV

Further description from the registry

In Parkinson's disease , there is a shifting of autonomic nerve function towards sympathetic dominance and Heart rate variability decrease. Reduced heart rate variability can be detected by Heart rate variability(HRV) testing. In Parkinson's disease deposition of Lewy bodies (due to accumulation of alpha- synuclein protein ) causes degeneration of dopaminergic neuron. Parasympathetic nerve results from vagus nerve atrophy and simultaneous sympathetic denervation results in decrease HRV. Hypovitaminosis D is commonly associated with Parkinson's disease due to alteration of gastrointestinal function, progressive skin atrophy, lack of mobilization, lack of sun exposure. Vitamin D3 act as neuroprotective hormone and plays role in autonomic nervous system regulation and maintaining balance between sympathetic and parasympathetic nervous system. Vitamin D3 deficiency is associated with cardiac autonomic imbalance. Administration of vitamin D3 in vitamin D deficient Parkinson's patient may may improve cardiac autonomic nerve function that can be interpreted by HRV.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT07084597 ↗ — RECRUITING; checked 2026-10-13
ClinicalTrials.gov · NCT07084597 ↗ — Recruiting; WHO ICTRP processed 2025-09-08; checked 2026-10-13

Study type: Interventional
Interventions: Vitamin D
Phases: NA
Sponsor: Bangladesh Medical University
Start date reported by registry: 2025-07 (estimated)

Registry updated: 2025-07-29 · Status last verified by the registry submitter: 2025-07

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Registrar BMU · +880255165708 · registrar@bsmmu.edu.bd

Jobayda Jobayda, MBBS,MD resident,Phase B · 01773845305 · jbinterohmotullah@gmail.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Bangladesh Medical University

Dhaka, Shahbag, Bangladesh

Recruiting

Jobayda Jobayda, MBBS,MD(Phase B)

Facility not reported

Bangladesh

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.