Recruiting · registry statusTrying a vibration-based tremor device at home
Participants try prototype devices that deliver targeted mechanical stimulation while researchers assess usability and effects on shaking.
Testing a treatment or activity · Study reference: NCT07078422
Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓
This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.
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Looking for volunteers
- Start (reported actual date)
- 2025-01-01
- Main measurements finished (planned)
- 2025-12
- Study finished (planned)
- 2026-06
Planned dates can move. A study finishing does not tell us when a paper will be published.
No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.
Changes we have recorded
These are dates we observed a change, not necessarily the dates it happened.
Papers connected to this study
No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.
Who can join?
Age 18 years and over · Does not accept healthy volunteers
These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.
Read all the rules for taking part
Sex eligibility reported by registry: all
Inclusion Criteria - Alpha and Beta Phase B1
* Age 18 years or older, able to comply with all study procedures and capable of providing informed consent.
* Mentally competent to understand and able to perform written, informed consent to participate in the study
* A diagnosis of either ET or PD as determined by clinical history
* Moderate to severe upper limb tremor
Exclusion Criteria - Alpha and Beta Phase B1
* Pregnant women
* Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site
* History of psoriasis, eczema or atopic dermatitis at the stimulation site
* History of peripheral neuropathy in the upper limbs, including carpal tunnel syndrome and diabetic neuropathy
* Participant unable to communicate with sponsor/investigator and staff
* Any other medical conditions or physical or mental impairments that in the sponsor/investigator's opinion would render the subject unsuitable as a candidate for the study.
Inclusion Criteria - Beta Phase B2
* Age 18 years or older, able to comply with all study procedures and capable of providing informed consent
* Mentally competent to understand and able to perform written, informed consent to participate in the study
* For ET subjects, a diagnosis of essential tremor defined as definite or probable ET based on TRIG criteria
* For PD subjects, a diagnosis of Parkinson's disease by a Movement Disorder Specialist
* For ET subjects, at least one hand exhibiting tremor \> 2 as assessed by the Essential Tremor Rating Assessment Scale (TETRAS) finger to nose task, duck wing task, OR Archimedes Spiral completed during the Screening visit
* For PD subjects, a score \> 2 on at least one of MDS-UPDRS items 3.15, 3.16 or 3.17 At the Screening Visit, a score of \> 3 on one of the following subject-assessed items of the Bain \& Findley Activities of Daily Living Scale (BF-ADL): Use a spoon to drink soup, Hold a cup of tea, Do up buttons, Do up a zipper, Write a letter
* Stable medications for at least 30 days prior to enrollment and the ability to maintain tremor medications throughout the duration of study participation
* For PD subjects, able to participate in visits in a practically defined OFF state (withdrawal from all tremor medication for 12 hours prior to study visits)
* A wrist circumference of 6.0 - 8.1 inches
Exclusion Criteria - Beta Phase B2
* Pregnant women
* Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site
* History of psoriasis, eczema or atopic dermatitis at the stimulation site
* History of peripheral neuropathy in the upper limbs, including carpal tunnel syndrome and -diabetic neuropathy
* Participant unable to communicate with sponsor/investigator and staff
* Any other medical conditions or physical or mental impairments that in the sponsor/investigator's opinion would render the subject unsuitable as a candidate for the study
Full study name & original research details
Official study title
Home Use Study of Targeted Mechanical Stimulation for Tremor Relief
Original description
Subjects will receive prototype devices to be used for participation. The study comprises three phases:
1. Alpha phase: Two remote study visits and an in-home period to gather device usability data on the alpha system. The at home period for this phase will be 2 weeks. This phase will be used to confirm that the device and labeling are suitable for in-home use.
2. Beta Phase B1: Beta Phase B1 will be conducted using the beta devices for two in-person or remote, 60 to 90-minute, visits. This phase will be used to assess design changes between alpha and beta versions.
3. Beta Phase B2: Seven remote visits and in-home usage to gather usability and efficacy data on the beta system in-home. Beta Phase B2 will be conducted using the beta devices for 12 weeks. This phase will be used to assess design changes between alpha and beta versions.
Conditions reported: Essential Tremor; Parkinson's Disease
Registry records for this study
Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.
- Study type
- Interventional
- Interventions
- Encora Pulse
- Phases
- NA
- Sponsor
- Encora, Inc.
- Start date reported by registry
- 2025-01-01 (actual)
Registry updated: 2025-11-24 · Status last verified by the registry submitter: 2025-07
Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.
Contact the research team
Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.
Allison Davanzo · 855-937-5302 · alli@encoratherapeutics.com
Study locations
Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.
Encora Therapeutics
Cambridge, Massachusetts, United States
RecruitingAllison Davanzo · 855-937-5302 · alli@encoratherapeutics.com
Facility not reported
United States
Status not reportedThe original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.