Recruiting · registry status

Studying brain activity during challenging walking tasks

Researchers measure brain activity during complex walking tasks in people with conditions that resemble Parkinson’s.

Learning by observing or collecting information · Study reference: NCT06906276

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported actual date): 2025-03-14
Main measurements finished (planned): 2027-12-31
Study finished (planned): 2027-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age range not listed · Does not accept healthy volunteers

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Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * clinical diagnosis of PSP according to Movement Disorder Society (MDS) (2017) or * MSA according to MDS criteria (2022) * the ability to walk with or without a mobility device for ≤5 minutes continuously Exclusion Criteria: * cognitive difficulties affecting the ability to understand and/or follow verbal/written - instructions * severe freezing of gait * Severe hearing or visual impairments that affect participation in the assessments * Other neurological diseases * Other diseases that can affect gait or balance.

Full study name & original research details

Official study title

Walking and Thinking - Brain Activity During Complex Walking in Atypical Parkinsonian Syndromes

Short title used by the registry

Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes

Original description

Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as atypical Parkinson's disease (APD) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecologically valid state. The investigators aim therefore to explore brain function during complex walking in healthy and APD by investigating the effects of age and neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in older healthy adults and people with APD.

Conditions reported: Gait Disorders, Neurologic; Atypical Parkinson Disease; fNIRS; Aging

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT06906276 ↗ — RECRUITING; checked 2026-10-13
ClinicalTrials.gov · NCT06906276 ↗ — Recruiting; WHO ICTRP processed 2025-09-08; checked 2026-10-13

Study type: Observational
Interventions: Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
Phases: Not reported
Sponsor: Karolinska Institutet
Start date reported by registry: 2025-03-14 (actual)

Registry updated: 2025-07-08 · Status last verified by the registry submitter: 2025-03

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Compliance Office Karolinska Insitutet · +46852480000 · compliance@ki.se

Erika Franzén, Prof, · +46852488878 · erika.franzen@ki.se

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Karolinska Institutet

Solna, Solna, Sweden

Recruiting

Erika Franzén · 0046737121593 · erika.franzen@ki.se

Facility not reported

Sweden

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.