RESEARCH / PARTICIPATIONBack to the library
← Find a study
Recruiting · registry status

Understanding social information in Parkinson’s

Researchers study how people with Parkinson’s interpret social information and the brain processes involved.

Testing a treatment or activity · Study reference: NCT06884722

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

Open the official registry record ↗

Follow this study

Looking for volunteers

Start (reported actual date)
2025-07-15
Main measurements finished (planned)
2027-04
Study finished (planned)
2027-04

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 30 years to 75 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Male or female between 30 and 75 years of age * Freely-given informed consent to participate to this study (written form) * Affiliated with a social security system or equivalent; * Person diagnosed with Parkinson's disease according to MDS-UPDRS criteria for at least 3 years and receiving dopaminergic treatment (e.g. : LEVODOPA, CARBIDOPA, BENZERASIDE, ENTACAPONE, MODOPAR, SINEMET, STALEVO, PRAMIPEXOLE, SIFROL, ROPINIROLE, REQUIP ; ROTIGOTINE, NEUPRO, PIRIBEDIL, TRIVASTAL, RASAGILINE, AZILECT, CONTAM, AMANTADINE, MANTADIX, APOMORPHINE, APOKINON, DOPACEPTIN, FOSLEVODOPA, FOSCARBIDOPA, SCYOVA) (for patients only) * Effective contraception for women of childbearing age or post-menopausal women (only for patients and healthy volunteers in stage 2 "imaging") * Requiring dopa testing as part of routine care (only for patients in stage 2 "imaging") * No disabling cognitive impairment (MOCA score ≥ 26) * No diagnosis of chronic disease associated with disability (only for healthy volunteers) Exclusion Criteria: * Contraindication to MRI (only for patients and healthy volunteers in step 2 "imaging"): * Wearing a pacemaker not approved for 3 Tesla MRI * Presence of intracerebral ferromagnetic or magnetizable material * Presence of intraocular ferromagnetic or magnetizable foreign bodies * Presence of non-removable ferro-magnetic or magnetizable foreign bodies in the cephalic region * Claustrophobia * History of head trauma with loss of consciousness lasting more than 30 min (only for patients and healthy volunteers in step 2 "imaging") * Participant not agreeing to be informed in the event of incidental discovery of an abnormality on MRI (only for patients and healthy volunteers in stage 2 "imaging") * Tremor or disabling dyskinesias preventing MRI (only for patients in stage 2) * Having exceeded the annual amount of compensation allowed for participation in research protocols (only for healthy volunteers) * Pregnant, parturient or breast-feeding women * Persons deprived of liberty by judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults under legal protection (guardianship, curatorship) * Participants in other intervention research involving a period of exclusion still in progress at the time of pre-inclusion.
Full study name & original research details

Official study title

Social Perception and Dopaminergic Modulation in Patients With Parkinson's Disease: a Functional MRI Study (Park Social-E-Motion)

Short title used by the registry

Brain Mechanisms of Social Perception in Parkinson's Disease

Original description

Social cognition is a complex process that enables humans to interpret social information and behave appropriately in a social environment. Social cognition can be impaired in Parkinson's disease patients, worsening quality of life and relationships with those around them, even at an early stage. These alterations are manifested in particular by impairments of the recognition of facial emotions and body movements, involving the motor system. The aim of this study is to understand the brain mechanisms associated with impaired social perception in people with Parkinson's disease using functional MRI and a behavioural task for the perception of social interaction scenes depicted by "Point Light Display" (PLD).This study will investigate the effect of dopaminergic modulation on the networks associated with the perception of movement and mirror system, the observation of action (parietal cortex, superior temporal sulcus), and those associated with the mentalization of others' cognitive or emotional states (prefrontal cortex and limbic system). The study is thus divided into 2 stages. * Stage 1 "preliminary": Preliminary validation of the experimental task * Stage 2 "imagery": Assessment of brain activity (BOLD signal) related to social perception in imaging

Conditions reported: Social Perception in Parkinson's Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Behavioral task of social perception (stage 1); Functional magnetic resonance imaging: 3 Tesla magnetic resonance imaging (stage 2); Neurological and neuropsychological assessments; Neurological assessments of Parkinson's disease symptoms and caregiver burden
Phases
NA
Sponsor
Hospices Civils de Lyon
Start date reported by registry
2025-07-15 (actual)

Registry updated: 2025-07-22 · Status last verified by the registry submitter: 2025-07

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Stéphane PRANGE, MD, PhD · 472 357 222 · stephane.prange@chu-lyon.fr

Elise METEREAU · 427 856 208 · elise.metereau@chu-lyon.fr

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Service de neurologie - troubles du mouvement et pathologies neuromusculaires, Hôpital neurologique Pierre Wertheimer/GHE

Bron, France

Recruiting

Stéphane PRANGE, MD, PhD · 472 357 222 · stephane.prange@chu-lyon.fr

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.