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Following changes in connections between brain cells

Researchers use repeated brain scans to study changes over time in the connections through which nerve cells communicate.

Testing a treatment or activity · Study reference: NCT06875765

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date)
2025-07-16
Main measurements finished (planned)
2027-12
Study finished (planned)
2027-12

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 30 years and over · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Participation in study S61477 (NCT04243304) Exclusion Criteria: * Neuropsychiatric diseases (unrelated to PD for PD patients) * Major internal medical diseases * History of alcohol or drug abuse * Relevant abnormalities on MR brain * Contraindications for MR * Pregnancy or breastfeeding * Previous participation in other research studies involving ionizing radiation with \> 1 mSv over past 12 months.
Full study name & original research details

Official study title

Longitudinal Measurement of Synaptic Loss and Cognitive Decline in the Long-term Course of Parkinson's Disease

Short title used by the registry

Long-term Longitudinal Imaging of Presynaptic Terminals in PD

Original description

AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD. STUDY DESIGN: The investigators will re-invite participants (both patients with PD and healthy controls) of a previous longitudinal study (NCT04243304, S61477) to undergo evaluation approximately 7 years after the initial baseline study visit (i.e. on average 10 years since the first motor symptoms). All participants will undergo clinical assessment of motor and non-motor symptoms (including cognitive testing), as well as 11C-UCB-J PET-CT (targeting synaptic density marker SV2A), 18F-FE-PE2I PET-CT (targeting DAT) and brain MRI.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
11C-UCB-J PET-CT; 18F-PE2I PET-CT; MRI brain
Phases
NA
Sponsor
Universitaire Ziekenhuizen KU Leuven
Start date reported by registry
2025-07-16 (actual)

Registry updated: 2025-07-29 · Status last verified by the registry submitter: 2025-07

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Wim Vandenberghe, MD, PhD · +3216344280 · wim.vandenberghe@uzleuven.be

Jolien Van Opstal, MD · +3216338052 · jolien.vanopstal@uzleuven.be

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

UZ Leuven

Leuven, Belgium

Recruiting

Jolien Van Opstal, MD · +16338052 · jolien.vanopstal@uzleuven.be

Wim Vandenberghe, MD, PhD

Koen Van Laere, MD, MSc, PhD

Aline Delva, MD, PhD

Jolien Van Opstal, MD

Facility not reported

Belgium

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.