Recruiting · registry status

Recording brain activity involved in planning and thinking

Researchers use detailed recordings from the brain to study how its cells support planning and other thinking skills.

Testing a treatment or activity · Study reference: NCT06778135

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date): 2025-07-25
Main measurements finished (planned): 2027-10
Study finished (planned): 2027-12

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 45 years to 85 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1. Diagnosis of Parkinson's disease and refractory to medications requiring deep brain stimulation 2. Aged 45-85 3. Able to provide informed consent 4. Normal neuropsychiatric evaluation that includes tests of executive function demonstrating no greater than mild impairments, within expectation for Parkinson's disease. 5. Medically able to undergo deep brain stimulation surgery as evaluated by study neurosurgeon. 6. Surgical plan includes an entry point that can safely be placed in the dorsal lateral PFC. 7. Able to tolerate awake deep brain stimulation surgery with a plan for the case to be done awake. 8. Able to tolerate 25 additional minutes of awake surgery. 9. Able to participate and comply with tasks adequately, including instructions provided in English. Exclusion Criteria: 1. Moderate, or severe cognitive impairment as determined by a licensed neuropsychologist during routine neuropsychological evaluation. 2. Inability to tolerate awake surgery as determined by the treating neurologist and study neurosurgeon. 3. Inability to safely access the dorsal lateral prefrontal cortex for an entry location. 4. Moderate or severe cognitive impairment or executive function deficits as determined by neuropsychological testing. 5. Evidence of a clinically significant abnormality on preoperative imaging.

Full study name & original research details

Official study title

Neocortical Microarchitecture of Executive Function Using Large-scale Intracranial Electrophysiology

Short title used by the registry

Neocortical Microarchitecture of Executive Function

Original description

This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.

Further description from the registry

This project aims to use Neuropixels probes to record hundreds of neurons during awake human intracranial surgeries. Using this probe, we will take advantage of access to a key area in the network involved in executive function, the middle frontal gyrus of the dorsal lateral Pre Frontal Cortex (approximately the mid portion of dlPFC, part of Brodmann area 9/46), to test emerging concepts that cognitive flexibility so crucial to human EF is encoded in neural population geometry and layer-specific interactions.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT06778135 ↗ — RECRUITING; checked 2026-10-13
ClinicalTrials.gov · NCT06778135 ↗ — Recruiting; WHO ICTRP processed 2025-09-29; checked 2026-10-13

Study type: Interventional
Interventions: Temporary implatation of large-scale intracranial electrode.; brain electrode
Phases: NA
Sponsor: University of Colorado, Denver
Start date reported by registry: 2025-07-25 (actual)

Registry updated: 2025-09-17 · Status last verified by the registry submitter: 2025-09

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Pamela David Gerecht, PhD · 303-724-4134 · pamela.davidgerecht@cuanschutz.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

University of Colorado

Aurora, Colorado, United States

Recruiting

Pamela David Gerecht, Ph.D. · 303-724-4134 · pamela.davidgerecht@cuanschutz.edu

Daniel R Kramer, MD

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.