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Managing high homocysteine levels during levodopa treatment

Researchers investigate treatment to lower raised blood homocysteine, a substance made by the body, in people with Parkinson’s taking levodopa.

Testing a treatment or activity · Study reference: NCT06772220

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date)
2024-03-05
Main measurements finished (planned)
2025-12-31
Study finished (planned)
2025-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 40 years to 90 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1. Diagnosis of probable Parkinson's Disease according to Movement Disorders Society criteria. 2. Currently treated with levodopa at a minimum dose of 300 mg/day 3. Montreal Cognitive Assessment (MOCA) ≥15 4. Demonstrated capacity to provide informed consent. 5. 40-90 years of age 6. Estimated glomerular filtration rate ≥60 7. Absence of uncontrolled hypertension in medical history 8. Absence of insulin use Exclusion Criteria: \-
Full study name & original research details

Official study title

Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease

Original description

This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.

Conditions reported: Parkinson&Amp;#39;s Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Folic Acid 1 MG; Vitamin B6 25 MG; Vitamin B12
Phases
NA
Sponsor
Oregon Health and Science University
Start date reported by registry
2024-03-05 (actual)

Registry updated: 2025-01-13 · Status last verified by the registry submitter: 2025-01

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Madeline Armendariz Sullivan · 503-501-8478 · PDResearch@ohsu.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Oregon Health & Science University (OHSU)

Portland, Oregon, United States

Recruiting

Madeline Armendariz Sullivan · 503-501-8478 · PDResearch@ohsu.edu

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.