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Comparing outcomes after brain surgery

Researchers collect treatment results across centres to understand what influences outcomes after neurosurgical care.

Learning by observing or collecting information · Study reference: NCT06724029

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date)
2022-12-05
Main measurements finished (planned)
2027-06
Study finished (planned)
2027-06

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 18 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Neuro-oncological pathology: supratentorial and subtentorial tumors, intra and extra axial tumors excluding the skull base (anterior, middle and posterior fossa; sellar and parasellar region) * Basicranial pathology: tumors originating from the anterior cranial fossa, middle cranial fossa and posterior cranial fossa, sellar region with or without supratentorial/parasellar development. * Vascular pathology: aneurysms, AVMs, cavernomas, other pathologies (Moyamoya disease, dural fistulas, nontraumatic hematomas) * Traumatic pathology: diffuse damage (nonvisible diffuse damage, diffuse damage, diffuse damage with edema, diffuse damage with shift) and focal damage (acute/subacute/chronic subdural hematoma, extradural hematoma, subarachnoid hemorrhage, intraparenchymal hematoma, fractures); hydrocephalus. The inclusion criterion for chronic subdural hematoma is recent bleeding for TBI with CT finding of chronic subdural hematoma candidate for evacuation surgery. * Spinal pathology: degenerative cervical (anterior/posterior), myelopathic, and trauma pathology; instrumented, uninstrumented thoracolumbar pathology (disc pathology, canal pathology), and trauma pathology; oncologic spinal pathology. * Functional pathology: Parkinson's disease, spasticity, trigeminal neuralgia, craniofacial pain/algia, neuropathic pain, tremor, dystonias, obsessive compulsive disorder, drug-resistant epilepsies, depression. Normotensive hydrocephalus. * Peripheral nervous system pathology: peripheral nerve compression syndromes, peripheral nerve and plexus tumors, brachial plexus and peripheral nerve trauma (contusion and section) * Malformative pathology: Chiari malformation type 1 and craniostenoses including both those framed in malformative syndromes and those not framed in malformative syndromes (monosutural craniostenoses: trigonocephaly, plagiocephaly, scaphocephaly; multisutural craniostenoses). Malformative hydrocephalus. * For cognitive and psychological assessment: age 18 years or older; adequate understanding of Italian language; diagnosis of glioma, meningioma, vascular pathology, spinal pathology Exclusion Criteria: * For cognitive and psychological assessment: patients with psychiatric diseases in history and/or taking psychotropic drugs; presence of overt cognitive decline (not due to the injury) in history; patients younger than 18 years old.
Full study name & original research details

Official study title

Neurosurgical Outcome Network Per la Predizione Dell'Outcome in Neurochirurgia

Short title used by the registry

Neurosurgical Outcome Network

Original description

The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared. This study aims to assess outcomes and their predictors using measures agreed upon by the participating centers. Standardizing the evaluation of outcomes and predictors improves the quality of research, allows for data comparison, and facilitates a "common language" in routine clinical practice. Most importantly, it influences therapeutic decisions in various neurosurgical conditions. Clinically, the identified predictors can also be used during preoperative assessments to provide more precise guidance to patients undergoing surgery.

Further description from the registry

The evaluation of outcome indicators, quality of life, and complexity in Neurosurgery has gained significant importance not only at a clinical and therapeutic level but also as a tool to assess the effectiveness and efficiency of the healthcare system. This study aims to evaluate neurosurgical outcomes and their predictors using measures shared among participating centers. Such evaluation varies from center to center, and the predictive factors are not entirely known or shared. Standardizing the evaluation of outcomes and predictors improves research quality, enables data comparison, and fosters a common language in everyday clinical practice. Most importantly, it influences therapeutic decisions in various neurosurgical pathologies. Primary Objective: Collect and describe the pre- and postoperative clinical, cognitive, and psychological status in various neurosurgical pathologies. Secondary Objectives: Identify outcome predictors. Primary Endpoint: Description of pre- and postoperative clinical, cognitive, and psychological data of patients undergoing neurosurgical intervention. Secondary Endpoints: Analyze the association between preoperative indicators collected and postoperative outcomes. Specific predictors and outcome measures for each neurosurgical pathology will be considered and reported in Appendix 1. Patient enrollment from Neurosurgery Departments; collection of clinical, cognitive, and psychological data before the intervention and during follow-up after the intervention (timing varies depending on the neurosurgical pathology); data analysis through AI. For all neurosurgical pathologies, the following data will be collected: sociodemographic, clinical (Charlson Comorbidity Index, heart disease, diabetes, Chronic Obstructive Pulmonary Disease, hypertension, Body Mass Index, smoking, psychiatric pathology, admission date, intervention date, discharge date, Modified Rankin Scale, American Society of Anesthesiologists, weight, height), anesthesiological (collected only by FINCB), and complication-related data (Novel Therapy-Disability-Neurology).

Conditions reported: Aneurysms; Arteriovenous Malformations; Cavernomas; Skull Base Tumors; Moyamoya Disease; Dural Fistulas; Subdural Hematoma; Extradural Hematoma; Subarachnoid Hemorrhage; Hydrocephalus; Parkinson&Amp;#39;s Disease; Spasticity; Trigeminal Neuralgia; Craniofacial Pain; Neuropathic Pain; Tremor; Dystonias; Obsessive-compulsive Disorder; Drug-resistant Epilepsy; Depression; Normal Pressure Hydrocephalus; Tumors of Peripheral Nerves; Chiari Malformation Type 1

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Not reported
Phases
Not reported
Sponsor
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Start date reported by registry
2022-12-05 (actual)

Registry updated: 2026-03-30 · Status last verified by the registry submitter: 2026-03

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Paolo Ferroli, MD · +39 02 2394 2411 · paolo.ferroli@istituto-besta.it

Morgan A Broggi, MD · +39 02 2394 2411 · morgan.broggi@istituto-besta.it

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

1. ASST Papa Giovanni XXIII

Bergamo, BG, Italy

In progress; recruitment closed

Spedali Civili Brescia

Brescia, BS, Italy

In progress; recruitment closed

Fondazione Poliambulanza Istituto Ospedaliero

Brescia, BS, Italy

In progress; recruitment closed

Ospedale Moriggia Pelascini

Gravedona, Como, Italy

In progress; recruitment closed

ASST Lariana, Ospedale S. Anna

Como, CO, Italy

In progress; recruitment closed

ASST Cremona

Cremona, CR, Italy

In progress; recruitment closed

Fondazione IRCCS San Gerardo dei Tintori

Monza, MB, Italy

In progress; recruitment closed

Fondazione IRCCS Policlinico San Matteo

Pavia, PV, Italy

In progress; recruitment closed

ASST della Valtellina ed Alto Lario

Sondrio, SO, Italy

In progress; recruitment closed

Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"

Catania, Italy

Recruiting

Giuseppe Barbagallo, MD · 095 - 479 4473 · giuseppebarbagal@hotmail.com

Giuseppe Barbagallo, MD

Azienda Ospedaliero Universitaria Careggi

Florence, Italy

Recruiting

Alessandro Della Puppa, MD · 055 794 8327 · alessandro.dellapuppa@unifi.it

Alessandro Della Puppa, MD

Ospedale F. Spaziani di Frosinone

Frosinone, Italy

Recruiting

Giancarlo D'Andrea, MD · 07751802907 · giancarlo.dandrea@aslfrosinone.it

Giancarlo D'Andrea, MD

Ospedale Alessandro Manzoni

Lecco, Italy

In progress; recruitment closed

ASST Ovest Milanese

Legnano, Italy

In progress; recruitment closed

Ospedali Riuniti di Livorno -Azienda USL Toscana nord ovest

Livorno, Italy

Recruiting

Gianluca Grimod, MD · 0586/223111 · gianluca.grimod@uslnordovest.toscana.it

Gianluca Grimod, MD

Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, Italy

Recruiting

Paolo Ferroli, MD · +39 02 2394 2411 · paolo.ferroli@istituto-besta.it

Morgan A Broggi, MD · + 39 2394 2411 · morgan.broggi@istituto-besta.it

Paolo Ferroli, MD

Morgan A Broggi, MD

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, Italy

In progress; recruitment closed

ASST Santi Paolo e Carlo

Milan, Italy

Recruiting

Marcello Egidi, MD · 02 4022 2079 · marcello.egidi@asst-santipaolocarlo.it

Marcello Egidi, MD

ASST Fatebenefratelli Sacco

Milan, Italy

In progress; recruitment closed

Istituto Clinico Città Studi

Milan, Italy

In progress; recruitment closed

Policlinico di Monza

Monza, Italy

Recruiting

Michele Incerti, MD · 3662357286 · micheleincerti@libero.it

Michele Incerti, MD

A.R.N.A.S. Ospedali Civico di Palermo

Palermo, Italy

Recruiting

Giovanni Tringali, MD · 0916663179 · giovanni.tringali@arnascivico.it

Giovanni Tringali, MD

Azienda Ospedaliero Universitaria di Parma

Parma, Italy

In progress; recruitment closed

ASL Roma 1

Roma, Italy

Recruiting

Flavia Fraschetti, MD · +39 06 6010.2350 · flavia.fraschetti@gmail.com

Flavia Fraschetti, MD

Fondazione Policlinico Universitario Gemelli di Roma

Roma, Italy

Recruiting

Massimiliano Visocchi, MD · 06 3015 4408 · massimiliano.visocchi@policlinicogemelli.it

Massimiliano Visocchi, MD

IRCCS Istituto Clinico Humanitas

Rozzano, Italy

In progress; recruitment closed

Azienda Sanitaria Universitaria Friuli Centrale di Udine

Udine, Italy

Recruiting

Marco Vindigni, MD · 0432552701 · marco.vindigni@asufc.sanita.fvg.it

Marco Vindigni, MD

Facility not reported

Italy

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.