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Distinguishing different forms of muscle stiffness

Researchers study ways to assess and distinguish different causes of increased muscle resistance in conditions such as Parkinson’s and spinal cord injury.

Testing a treatment or activity · Study reference: NCT06596187

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Start (reported actual date)
2024-10-09
Main measurements finished (planned)
2026-08
Study finished (planned)
2026-08

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

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Who can join?

Age 20 years and over · Also accepts healthy volunteers

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Read all the rules for taking part

Sex eligibility reported by registry: all

Health subjects: Exclusion Criteria: 1. Musculoskeletal injuries on legs. 2. Osteoporosis. SCI subjects: Inclusion Criteria 1. Participants with chronic spinal cord injury, with injury duration greater than one year. Exclusion Criteria 1. Current musculoskeletal or joint injuries in the lower limbs. 2. History of central or peripheral neuromuscular diseases. 3. Presence of a pacemaker. 4. Current use of antispastic or antidepressant medications. 5. Current venous thromboembolism or osteoporosis. 6. Impairment of the soleus H-reflex arc. PD subjects: Inclusion Criteria: \- Clinical diagnosis of Parkinson disease. Exclusion Criteria: 1. Musculoskeletal injuries on legs 2. Osteoporosis. 3. Any peripheral or central nervous system injury or disease patients.
Full study name & original research details

Official study title

Differential Assessment of Hypertonia Related to CNS Impairment

Short title used by the registry

Differential Assessment of Hypertonia

Original description

Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However, recent studies suggest that rigidity may also be influenced by stretch velocity. This study aims to investigate muscle tone by examining spasticity, rigidity, and normal muscle function through neural and biomechanical changes. Standard clinical tools, such as the Modified Ashworth Scale and Unified Parkinson's Disease Rating Scale, along with additional assessments like the Myoton and Post-Activation Depression (PAD), will be employed.

Further description from the registry

Spasticity and rigidity are common symptoms resulting from central nervous system injuries (e.g., spinal cord injury and Parkinson's disease). During passive joint movement, spasticity and rigidity manifest as two distinct patterns of increased resistance. Spasticity is a type of hypertonia characterized by a stretch reflex that increases with speed, accompanied by exaggerated tendon reflexes. Rigidity, on the other hand, is another form of hypertonia, where resistance increases during passive movement and remains consistent throughout the range of motion. The degree of rigidity is traditionally considered independent of stretch velocity, which is one of the key differences from spasticity. However, recent studies have found that rigidity may also increase with stretch velocity. Despite attempts to distinguish different types of hypertonia based on stretch velocity, these efforts have largely been unsuccessful. Many factors influence muscle tone, which can be broadly categorized into changes in neural and biomechanical properties. The Modified Ashworth Scale and the Unified Parkinson's Disease Rating Scale are the most commonly used clinical tools for assessing spasticity and rigidity. Additionally, devices such as the Myoton or laboratory parameters like Post-Activation Depression (PAD) are also used for assessment.

Conditions reported: SCI - Spinal Cord Injury; PD - Parkinson's Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Continuous passive motion device (CPM) of ankle - fast; Continuous passive motion device (CPM) of ankle - slow
Phases
NA
Sponsor
Chang Gung University
Start date reported by registry
2024-10-09 (actual)

Registry updated: 2024-10-15 · Status last verified by the registry submitter: 2024-10

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Ya-Ju Chang, PhD · +88632118800 · yjchang@mail.cgu.edu.tw

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Chang Gung University

Taoyuan, Taiwan

Recruiting

Ya-Ju Chang, PhD · 88632118800 · yjchang@mail.cgu.edu.tw

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.