Recruiting · registry status

Using biological markers to better predict dementia progression

Researchers combine biological measurements and computer models to predict changes across conditions that cause thinking difficulties and dementia.

Learning by observing or collecting information · Study reference: NCT06529744

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

Open the official registry record ↗

Follow this study

Looking for volunteers

Start (reported actual date): 2023-11-11
Main measurements finished (planned): 2026-11
Study finished (planned): 2027-11

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 30 years to 95 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Possible or probable diagnosis of MCI or early dementia * Age 30-95 * Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits. * Must, in the opinion of the site investigator, be able to complete most study procedures. Exclusion Criteria: * Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.

Full study name & original research details

Official study title

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Original description

To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).

Further description from the registry

The goal of this study is to create a model to predict disease progression in patients with mild cognitive impairments and forms of dementia. To accomplish this, the current study will evaluate different tests including: brain imaging (MRI), body fluid samples (blood and cerebrospinal fluid), skin biopsy, cognitive ability, and behavioural questionnaires. The study team hopes that this information can be used to guide diagnosis and better predict disease progression in patients with mild cognitive impairment and and early dementia.

Conditions reported: Dementia; Alzheimer Disease; Dementia With Lewy Bodies; Vascular Dementia; Frontotemporal Dementia; Mild Cognitive Impairment; Corticobasal Syndrome; Progressive Supranuclear Palsy; Parkinson Disease; Primary Progressive Aphasia

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT06529744 ↗ — RECRUITING; checked 2026-10-13
ClinicalTrials.gov · NCT06529744 ↗ — Recruiting; WHO ICTRP processed 2025-12-01; checked 2026-10-13

Study type: Observational
Interventions: Not reported
Phases: Not reported
Sponsor: University Health Network, Toronto
Start date reported by registry: 2023-11-11 (actual)

Registry updated: 2025-11-20 · Status last verified by the registry submitter: 2025-11

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Claudia Clementi, HBSc · 416-603-5914 · claudia.clementi@uhn.ca

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Baycrest

North York, Ontario, Canada

Not yet recruiting

Aymin Mumtaz · 416-785-2500 · amumtaz@research.baycrest.org

Morris Freedman, MD

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Not yet recruiting

Ljubica Zotovic · 416-480-6100 · ljubica.zotovic@sunnybrook.ca

Sandra E Black, MD

Toronto Western Hospital, University Health Network

Toronto, Ontario, Canada

Recruiting

Claudia Clementi · 416-603-5914 · claudia.clementi@uhn.ca

Maria C Tartaglia, MD

Centre for Addiction and Mental Health

Toronto, Ontario, Canada

Not yet recruiting

Loreque Fearon, BASc · 416-535-8501 · Loreque.Fearon@camh.ca

Tarek Rajji, MD

Sanjeev Kumar, MD

Facility not reported

Canada

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.