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Understanding how people control their actions

Researchers study action regulation and behaviour in people with Parkinson’s.

Testing a treatment or activity · Study reference: NCT06489483

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date)
2024-04-24
Main measurements finished (planned)
2026-11
Study finished (planned)
2027-11

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 years to 80 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

For Parkinson's Disease Patients: Inclusion Criteria: * Diagnosis of Parkinson's Disease by a movement disorder neurologist * Levodopa responsive with clearly defined "on" periods, with at least 30% improvement in UPDRS III scores on vs off * Willingness and ability to complete the behavioral experiments for up 3.5 hours * No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators Exclusion Criteria: * Patients with history of secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's Disease * Patients with a disease or condition that prevents understanding or communication of informed consent, study demands, and testing protocol including cognitive decline, diagnosed forms of dementia, significant memory impairment (MoCA\<23), or hearing loss that prevents adequate communication with researcher For Healthy subjects: Inclusion Criteria: * No history any diagnosed neurological disease(s), including movement disorders or cognitive decline * No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators
Full study name & original research details

Official study title

Revealing the Action Regulation Mechanisms in the Human Brain

Short title used by the registry

Action Regulation Behavioral

Original description

Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. Given that the decline of muscle control such as tremors, with difficulty walking or the ability to switch tasks once in movement, greatly affects the quality of daily life. Action regulation is a critical executive function (cognitive control over behavior), which includes actions such as suppressing activity when selecting between options, making decisions about stopping unwanted or inappropriate actions, and switching to new actions in response to environmental changes. Parkinson's disease (PD) has been shown to disrupt action inhibition which can be considered a measure to the progression of PD. The purpose of this research study is to better understand the mechanism of action regulations in PD patients and how action regulations in PD can be improved using dopaminergic treatment, which is a drug that either releases or involves dopamine, which is a neurotransmitter involved in sending signals to nerve cells. You are asked to participate in this research study because you are receiving a dopaminergic medication for treatment of your Parkinson's disease. There is currently no theory that integrates the mechanisms of action regulation into a unified framework, which this study aims to address. The researchers hope to learn more about the mechanisms of action regulation in PD patients and to help decrease action regulation disruptions in PD patients. This study will help characterize the motor behavior of PD patients.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
Action Regulation Movement Task
Phases
NA
Sponsor
University of Texas Southwestern Medical Center
Start date reported by registry
2024-04-24 (actual)

Registry updated: 2025-12-12 · Status last verified by the registry submitter: 2025-12

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Nader Pouratian, MD, Phd · (214) 645-5465 · nader.pouratian@utsouthwestern.edu

Sahil Chilukuri, BS · (214) 645-5465 · sahil.chilukuri@utsouthwestern.edu

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Recruiting

Sahil Chilukuri · sahil.chilukuri@utsouthwestern.edu

Nader Pouratian · nader.pouratian@utsouthwestern.edu

Facility not reported

United States

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.