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Understanding impulsive behaviour after brain stimulation

Researchers study brain connections that may help explain why some people become more impulsive after deep brain stimulation for Parkinson’s.

Testing a treatment or activity · Study reference: NCT06485986

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date)
2024-06-01
Main measurements finished (planned)
2026-08-01
Study finished (planned)
2026-08-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Age 18 years and over · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 years or above. * Diagnosed with Parkinson's disease who have required implanted STN electrodes for DBS in addition to their dopamine replacement therapy. * Diagnosed with or without (control group) impulse control disorders since the diagnosis of Parkinson's Disease. * Participant willing and able to sit in the MEG scanner and follow instructions. * Participant willing and able to delay their morning dose of dopamine replacement therapy for up to four hours (180 minutes experimental time + journey time). Exclusion Criteria: * Patients with extreme language barrier that cannot understand the purpose or instructions of the study despite the use of an interpreter. * Other implanted medical devices that may cause artefacts during MEG recordings. * Participants with a history of co-morbid neurological disorders. * Participant enrolled onto another clinical trial related to a neurological disorder (including Parkinson's disease) that may interfere with the results of this study. * Participants who are unable to sit still in a MEG scanner for the duration of this experiment e.g. patients with chronic pain or osteoarthritis. This will be assessed with their primary clinician
Full study name & original research details

Official study title

Frontosubthalamic Network Dynamics and Their Modulation During Impulse Control and Decision Making in Parkinson's Disease

Short title used by the registry

Frontosubthalamic Networks in Parkinson's Disease.

Original description

The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease. The main questions it aims to answer are: What are the distributed network effects of deep brain stimulation to the subthalamic nucleus? How does this correlate with increased impulsivity? Can alternative stimulation settings be used to minimize these? Participants will complete decision-making tasks whilst their deep brain stimulation devices are turned on and off with simultaneous magnetoencephalography recordings (a type of non-invasive brain scan that measures brain activity in real-time)

Conditions reported: Parkinson Disease; Impulse Control Disorder

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Interventional
Interventions
DBS on/off
Phases
NA
Sponsor
University of Oxford
Start date reported by registry
2024-06-01 (actual)

Registry updated: 2025-04-02 · Status last verified by the registry submitter: 2025-03

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

John Eraifej, BSc MBChB MRCS · 01865222763 · john.eraifej@ndcn.ox.ac.uk

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

John Radcliffe Hospital

Oxford, United Kingdom

Recruiting

John Eraifej, BSc MBChB MRCS · 01865222763

Facility not reported

United Kingdom

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.