Recruiting · registry status

Understanding changes in the sense of taste

Researchers compare taste and brain responses in people with early Parkinson’s, people with Lewy body disease, and volunteers without these conditions.

Testing a treatment or activity · Study reference: NCT06439355

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Who can join?

Age 18 years and over · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: Healthy volunteers: * Person who has given written consent * Adult * Enrolled in the national register of healthy volunteers * Fasting \> 2 hours before PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * No cognitive complaints and normal neurological assessment Patients with idiopathic Parkinson's disease: * Person who has given written consent * Adult * Fasting \> 2 hours before PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * Diagnostic criteria for established or probable IPD Patients with Lewy body disease: * Person who has given written consent * Adult * Fasting \> 2 hours prior to PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * Diagnostic criteria for probable or possible LBD Exclusion Criteria: * Non-affiliated to national health insurance * Person under legal protection (curatorship, guardianship) * Person subject to a court order * Pregnant, parturient or breast-feeding women * Major unable to give consent * MMSE score \< 15 and/or MoCA \< 10 * Known infection with COVID-19 in the 6 months prior to inclusion * Active smoker (\> 4 cigarettes per day on a regular basis) * Subject with pacemaker (contraindication for bioelectrical impedancemetry) * Diabetic (type 1 or type 2) * Taking medication (in progress at the time of the study) that interferes with gustation

Full study name & original research details

Official study title

Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis

Original description

The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: * healthy volunteers * patients with early Parkinson's disease * patients with incipient Lewy body disease. To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data. This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.

Conditions reported: Idiopathic Parkinson's Disease and Lewy Body Disease

Study type: Interventional
Interventions: Fasting blood test; Subject interview; Motor assessment; Neurocognitive assessment; Nutritional assessment; Taste tests
Phases: NA
Sponsor: Centre Hospitalier Universitaire Dijon
Start date reported by registry: 2024-05-27 (actual)

Registry updated: 2026-10-07 · Status last verified by the registry submitter: 2026-10

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Vincent SCHNEIDER · 03.80.29.30.89 · vincent.schneider@chu-dijon.fr

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Chu Dijon Bourgogne

Dijon, France

Recruiting

Vincent SCHNEIDER · 03.80.29.30.89 · vincent.schneider@chu-dijon.fr

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.