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Studying pesticide exposure and Parkinson’s risk

Researchers measure pesticides in urine and compare early signs associated with Parkinson’s to investigate links between exposure and risk.

Learning by observing or collecting information · Study reference: NCT06420310

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Looking for volunteers

Start (reported actual date)
2024-04-01
Main measurements finished (planned)
2028-09-30
Study finished (planned)
2028-12-30

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 45 years to 55 years · Also accepts healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Farmers exposed to pesticides for cases * No work exposure to pesticides for controls Exclusion Criteria: * Subjects without signed consent form * Neurological significant conditions
Full study name & original research details

Official study title

Prevalence of Preclinical and Prodromal Parkinson´s Disease in Subjects Exposed to Pesticides

Short title used by the registry

Pesticides and Parkinson´s Disease

Original description

The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD. We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs traditionally associated with PD in early forms.

Further description from the registry

Within different risk factors, pesticide exposure increases the risk of developing Parkinson's disease (PD) through epigenetic mechanisms by modifying the expression of genes related to PD and secondary mitochondrial dysfunction.We will conduct a cross-sectional prevalence study with cases (exposed to pesticides) and controls (not exposed to pesticides), randomly selecting 130 individuals in each group. Pesticide exposure will be determined through questionnaires.We will study the prevalence of preclinical and prodromal PD based on pesticide exposure, stratified by age and gender in the exposed, and non-exposed groups. Preclinical and prodromal PD will be assessed using: biological biomarkers and prodromal PD signs. Multivariate analyses will be employed to determine the risk of presenting early PD, adjusting for different clinical covariates. The results of this study will allow us to understand the early mechanisms associated with neurodegeneration and pesticides exposure.

Conditions reported: Pesticide-Induced Parkinsonism

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
exposure to pesticides
Phases
Not reported
Sponsor
Hospital Universitario de Burgos
Start date reported by registry
2024-04-01 (actual)

Registry updated: 2024-05-20 · Status last verified by the registry submitter: 2024-05

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

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Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Hospital Universitario de Burgos

Burgos, Spain

Recruiting

Esther Cubo, MD · +34947256533 · mcubo@saludcastillayleon.es

Facility not reported

Spain

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.