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Does a gene change affect the response to thinking exercises?

Researchers study whether changes in the GBA gene relate to how people with Parkinson’s respond to treatment that stimulates thinking skills.

Learning by observing or collecting information · Study reference: NCT06323278

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date)
2021-12-21
Main measurements finished (planned)
2026-12
Study finished (planned)
2027-12

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded
  • 2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 18 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: * Patients with Parkinson's disease according to the Gelb et al. criteria; * Patients who have carried out genetic screening for MP; * Patients who have a raw score in the range 15.50 to 22.23 at Montreal cognitive assessment (MoCA); * Patients who have signed the informed consent and the Privacy Policy; * Patients who are included in cognitive stimulation programs according to regular clinical practice. Exclusion Criteria: * Patients with the initial suspicion of MP that during the diagnostic work-up they were suffering from a different pathology; * Patients who have refused consent to participate in the study; * Patients with a diagnosis of MP and cognitive profile of dementia; * Patients undergoing deep brain neurostimulation (DBS-STN) treatment. Patients treated with DBS-STN were excluded because such treatment involves a surgical procedure whose effects on cognitive functioning could represent an interfering variable.
Full study name & original research details

Official study title

Evaluation of the Cognitive Stimulation Treatment in Patients With Parkinson's Disease

Short title used by the registry

Effectiveness of Cognitive Stimulation Treatment in Patients With Parkinson's Disease

Original description

The goal of this observational study is to evaluate the relationship between GBA mutation and cognitive stimulation treatment response in patients with Parkinson's disease. The main questions it aim to answer are: • assess whether the GBA mutation is associated with greater or lesser response to cognitive training treatment compared to a control group of PD patients without genetic mutations. • investigate the effect of cognitive stimulation program on behavioural aspects as secondary consequence induced by the possible improvement of cognitive abilities following treatment. Participants will be undergo to: - a neuropsychological evaluation describing their cognitive profile; - a genetic investigation and finally included in a cognitive stimulation programs according to regular clinical practice. Researchers will compare PD patients with GBA mutation and patients without genetic mutation to evaluate the effectiveness of cognitive stimulation treatment.

Conditions reported: Parkinson Disease

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

Study type
Observational
Interventions
Cognitive training
Phases
Not reported
Sponsor
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Start date reported by registry
2021-12-21 (actual)

Registry updated: 2024-03-21 · Status last verified by the registry submitter: 2024-03

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Fabiana Ruggiero, MSc in Psychology · +390255033621 · fabiana.ruggiero@policlinico.mi.it

Francesca Mameli, MSc in Psychology · +390255033621 · francesca.mameli@policlinico.mi.it

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, Italy

Recruiting

Fabiana Ruggiero, MSc in Psychology · +390255033621 · fabiana.ruggiero@policlinico.mi.it

Facility not reported

Italy

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.