Recruiting · registry status

Comparing diets and gut-microbe changes

Researchers compare a study diet with a standard diet over time, checking practicality and effects in people with Parkinson’s.

Testing a treatment or activity · Study reference: NCT06207136

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

This registry record was last updated over six months ago, or its update date is missing. Recruitment may have changed. Confirm with the team before making plans.

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Looking for volunteers

Start (reported actual date): 2024-12-03
Main measurements finished (planned): 2027-12-31
Study finished (planned): 2027-12-31

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Ages 40 years to 80 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: Eligible if the person living with Parkinson's has/is: 1. a clinical diagnosis of PD, 2. cognitively stable (no clinical dementia), 3. between 40-80 years old, 4. able to travel to UBC for 6 onsite visits over 18 months, 5. sufficient English proficiency (coaching and cooking classes are in English only), 6. on a stable dopaminergic medication for at least one month before baseline, 7. computer and internet access at home, and can be available via video link for at least 80% of the study sessions. Exclusion Criteria: Not eligible, if person has/is: 1. a diagnosis of atypical parkinsonism, 2. medical or psychiatric conditions that would prevent full participation in the nutrition intervention (such as food allergies), significant dysphagia, diabetes on insulin, anti-coagulation on warfarin, and inflammatory bowel disease, 3. clinical dementia, 4. unable to complete questionnaires or understand study instructions, 5. using of immunomodulatory agents, 6. used Probiotics in the last 4 weeks prior to study start, 7. used Antibiotics in the last 3 months prior to study start, 8. contraindications for MRI.

Full study name & original research details

Official study title

Canadian Parkinson's Microbiome Initiative: A Pilot Phase 2 Feasibility Randomized Controlled Trial of the MIND Diet in Parkinson's Disease

Short title used by the registry

Microbiome and Diet in Parkinson's Disease

Original description

The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia. Research has shown that eating components of Mediterranean diets are associated with a 30% lower risk to develop PD and a 40% lower mortality rate in those living with PD. Diet may influence the gut and microbiomes, thus may affect PD risk and progression. This study will examine how easy it will be to adhere to a certain type of diet for 18 months and what changes may occur in the gut microbiome and in PD symptoms on a specific diet during that time. The study will involve in-person study visits at UBC as well as online diet coaching sessions and online group cooking classes over Zoom. This is a randomized study, meaning that participants will be assigned by chance to either the Mediterranean-style diet group or the standard diet group for the duration of the 18 months. This pilot study will also examine recruitment rates and retention, in order to prepare for a larger future study.

Further description from the registry

Those meeting general eligibility criteria and are agreeable, will come to the University of British Columbia (UBC) for an onsite Screening visit to sign the consent form, review eligibility, and complete assessments. If the additional study criteria is met during the Screening and the 4-week run-in phase, an onsite Baseline assessment will occur over 2 days. At Baseline, each participant will be randomized to either (1) the "yellow cooking group", or (2) the "blue cooking group". Participants will remain in their assigned groups for the duration of the study. Participants will also be provided with a wearable wrist device to record daily physical movement and lifestyle factors during the 18 months. Participants in both groups will receive virtual/remote coaching (nutrition training) and group cooking classes, and also complete questionnaires (at home and in-person) and collect biological samples (urine, faecal). Onsite (in-person) visits will occur at Screening, Baseline, 3 months, 6 months, 12 months, and 18 months (end); these will include questionnaires, blood sample collections, participant feedback, magnetic resonance imaging (MRI) scans (Baseline and 18 months only).

Conditions reported: Parkinson Disease; Diet, Healthy; Gut Microbiome; Gastrointestinal Microbiome

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT06207136 ↗ — RECRUITING; checked 2026-10-11
ClinicalTrials.gov · NCT06207136 ↗ — Recruiting; WHO ICTRP processed 2026-03-30; checked 2026-10-11

Study type: Interventional
Interventions: Mediterranean-style diet
Phases: NA
Sponsor: University of British Columbia
Start date reported by registry: 2024-12-03 (actual)

Registry updated: 2026-03-23 · Status last verified by the registry submitter: 2026-03

Registry records retrieved 2026-10-11 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Annie Kuan · 604-827-0576 · annie.kuan@ubc.ca

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

UBC Pacific Parkinson's Research Centre

Vancouver, British Columbia, Canada

Recruiting

Annie Kuan · 604-827-0576 · annie.kuan@ubc.ca

Facility not reported

Canada

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.