Recruiting · registry status

Studying brain stimulation for thinking difficulties

Researchers use brain scans to investigate changes in brain connections after implanted or magnetic stimulation in people with Parkinson’s and thinking difficulties.

Learning by observing or collecting information · Study reference: NCT06090682

Plain-language introduction written with AI from the registry; not independently checked by a clinician. Read the original details below ↓

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Follow this study

Looking for volunteers

Start (planned): 2023-11-01
Main measurements finished (planned): 2026-11-01
Study finished (planned): 2027-11-01

Planned dates can move. A study finishing does not tell us when a paper will be published.

No results summary has been confirmed in the registry records we imported. See connected papers below; we keep checking after recruitment ends.

Changes we have recorded

2026-10-11 — recruiting

These are dates we observed a change, not necessarily the dates it happened.

Papers connected to this study

No connected paper has been found yet. The tracker checks the growing library for study identifiers and registry-linked publications.

Who can join?

Up to age 75 years · Does not accept healthy volunteers

These are starting points, not the full rules. The research team can tell you whether the study is right for your situation.

Read all the rules for taking part

Sex eligibility reported by registry: all

Inclusion Criteria: 1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS. Exclusion Criteria: Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.

Full study name & original research details

Official study title

Effect and Mechanism of Deep Brain Stimulation and Transcranial Magnetic Stimulation on Parkinson's Disease With Cognitive Impairment

Short title used by the registry

Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment

Original description

This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.

Further description from the registry

A variety of post-processing methods (VBM, SPM, CAT, LEAD-DBS, etc.) were used to analyze structural brain network images (sMRI, DTI) and functional brain network images (rs-fMRI, PET) based on connectomics, and combined with the changes of clinical symptoms before and after treatment. To study the mechanism of the influence of neural regulation on brain network, and further analyze how DBS and TMS improve the cognitive symptoms of PD patients from the perspective of brain connectomics, so as to explore the occurrence and development of Parkinson's disease with cognitive impairment and the possible improvement mechanism.According to the individual differences in clinical symptoms of different PD patients, better stimulation sites and the best brain network are sought to further guide the surgical plan, so as to obtain the best clinical treatment effect.

Conditions reported: Parkinson Disease; Cognitive Impairment

Registry records for this study

Records are joined using registration identifiers. Titles alone do not establish that two studies are the same.

ClinicalTrials.gov · NCT06090682 ↗ — RECRUITING; checked 2026-10-13
ClinicalTrials.gov · NCT06090682 ↗ — Recruiting; WHO ICTRP processed 2023-10-23; checked 2026-10-13

Study type: Observational
Interventions: Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)
Phases: Not reported
Sponsor: Tianjin Huanhu Hospital
Start date reported by registry: 2023-11-01 (estimated)

Registry updated: 2023-10-19 · Status last verified by the registry submitter: 2023-10

Registry records retrieved 2026-10-13 (UTC). Individual records may have older updates. Recruitment and eligibility must be confirmed with the study team.

Contact the research team

Public study contacts supplied to the registry. Ask whether recruitment is still open and what participation involves.

Zhao Guangrui, doctor · +86 18956405513 · Guangrui-Zhao@hotmail.com

Feng Keke, doctor · +86 18920195507 · fengke1976@163.com

Study locations

Site status can differ from overall study status. “Status not reported” means local availability needs confirmation. Remote participation and travel arrangements must be checked with the team.

Tianjin Huanhu Hospital

Tianjin, Tianjin Municipality, China

Recruiting

Yin Shaoya, doctor · +86 18622139285 · yinsya@hotmail.com

Facility not reported

China

Status not reported

The original descriptions and participation rules come from the registry. Participation is voluntary and does not guarantee benefit.